| Sep 23, 1999 |
LAST DOSE
technical
|
| Oct 04, 1999 |
treatment of BQL
technical
|
| Oct 05, 1999 |
RE: treatment of BQL
technical
|
| Jun 23, 2000 |
RE: weighted residuals
technical
|
| Jun 23, 2000 |
RE: weighted residuals
technical
|
| Sep 20, 2000 |
RE: An approach for imputing missing independent variable (covariate)
technical
|
| Sep 29, 2000 |
RE: Bayesian estimation
technical
|
| Nov 14, 2000 |
RE: 95% CI of parameter estimate
technical
|
| Nov 14, 2000 |
RE: 95% CI of parameter estimate
technical
|
| Mar 29, 2001 |
RE: Bootstrap resampling!
technical
|
| Mar 29, 2001 |
RE: Bootstrap resampling!
technical
|
| Mar 29, 2001 |
RE: Bootstrap resampling! -> Randomization test
technical
|
| May 07, 2001 |
RE: Unreasonable VSS estimate
technical
|
| May 07, 2001 |
=?utf-8?B?UkU6IFVucmVhc29uYWJsZSBWU1MgZXN0aW1hdGU=?=
technical
|
| May 08, 2001 |
RE: One ETA...for which parameter?
technical
|
| May 09, 2001 |
RE: Parameterization!!!
technical
|
| May 10, 2001 |
RE: Parameterization!!!
technical
|
| May 11, 2001 |
RE: Parameterization!!!
technical
|
| May 14, 2001 |
RE: Rich data set
technical
|
| May 24, 2001 |
RE: Error models and weighting
technical
|
| Jul 02, 2001 |
RE: Missing covariates
technical
|
| Jul 02, 2001 |
RE: Missing covariates
technical
|
| Jul 05, 2001 |
RE: Centering (was Re: Missing covariates)
technical
|
| Jul 30, 2001 |
RE: Centering (was Re: Missing covariates)
technical
|
| Oct 11, 2001 |
Re: Distributive Computing
technical
|
| Oct 26, 2001 |
glucose blood level measurements
technical
|
| Nov 02, 2001 |
Re: Problem (bug ?) with RATE and F1 in $PK
technical
|
| Nov 02, 2001 |
Re: Problem (bug ?) with RATE and F1 in $PK
technical
|
| Jan 14, 2002 |
censored data
technical
|
| Mar 08, 2002 |
Re: T matrix
technical
|
| Mar 11, 2002 |
Re: T matrix
technical
|
| Apr 03, 2002 |
Re: Capturing AUC between observation time intervals
technical
|
| Apr 23, 2002 |
Re: When to do transformation of data?
technical
|
| Apr 23, 2002 |
RE: When to do transformation of data?
technical
|
| Apr 23, 2002 |
RE: When to do transformation of data?
technical
|
| Apr 23, 2002 |
RE: When to do transformation of data?
technical
|
| May 02, 2002 |
RE: sequential PK/PD
technical
|
| May 08, 2002 |
Re: Oral pharmacokinetics sparse (no absorption phase)
technical
|
| May 17, 2002 |
Re: Placebo-corrected PD models
technical
|
| May 17, 2002 |
RE: Placebo-corrected PD models
technical
|
| Jul 12, 2002 |
Re: Endogenous drug
technical
|
| Jul 22, 2002 |
Re: Changing significant digits
technical
|
| Jul 30, 2002 |
Re: Not enough sex!
technical
|
| Sep 17, 2002 |
Re: Obtaining gradients for the computation of prediction intervals
technical
|
| Oct 04, 2002 |
Re: FW: OMEGA HAS A NONZERO BLOCK
technical
|
| Oct 04, 2002 |
RE: FW: OMEGA HAS A NONZERO BLOCK
technical
|
| Oct 04, 2002 |
RE: FW: OMEGA HAS A NONZERO BLOCK
technical
|
| Oct 07, 2002 |
RE: OMEGA HAS A NONZERO BLOCK
technical
|
| Oct 08, 2002 |
Re: OMEGA HAS A NONZERO BLOCK
technical
|
| Nov 19, 2002 |
Warning on xpose - S+ interaction
technical
|
| Jan 29, 2003 |
Re: FO vs FOCE (Any test?)
technical
|
| Feb 04, 2003 |
Re: CV
technical
|
| Mar 28, 2003 |
Re: Fixed or estimated?
technical
|
| Mar 31, 2003 |
Re: Log-transformation
technical
|
| Apr 01, 2003 |
RE: Describing variability
technical
|
| Apr 01, 2003 |
RE: Describing variability
technical
|
| Apr 02, 2003 |
RE: Describing variability
technical
|
| Apr 02, 2003 |
RE: Describing variability
technical
|
| Apr 11, 2003 |
Re: Error model
technical
|
| May 01, 2003 |
model diagnostics
technical
|
| May 05, 2003 |
Re: Using covariates with positive and negative values
technical
|
| May 14, 2003 |
Re: RE: ROUNDING ERRORS (ERROR=134)
technical
|
| May 15, 2003 |
Re: Math problem
technical
|
| May 22, 2003 |
Re: Poor PRED estimates
technical
|
| May 23, 2003 |
RE: Poor PRED estimates
technical
|
| May 27, 2003 |
RE: Poor PRED estimates
technical
|
| Jun 02, 2003 |
Re: Weighting in NONMEM
technical
|
| Jun 18, 2003 |
Re: PRED in a Hill binding model
technical
|
| Jun 27, 2003 |
Re: Omega Block off Diagonals
technical
|
| Jul 17, 2003 |
Re: Parameter %RSE vs ETA %RSE
technical
|
| Aug 06, 2003 |
RE: Non-physiological parameters at lowest OBJ
technical
|
| Aug 19, 2003 |
RE: Model estimates based on 1 sample per subject
technical
|
| Sep 25, 2003 |
Re: order of covariate inclusion
technical
|
| Sep 25, 2003 |
Re: order of covariate inclusion
technical
|
| Sep 25, 2003 |
RE: Re: order of covariate inclusion
technical
|
| Sep 25, 2003 |
Re: order of covariate inclusion
technical
|
| Sep 26, 2003 |
RE: order of covariate inclusion -> avoiding stepwise approaches -> abandoning exploratory analysis?
technical
|
| Sep 29, 2003 |
RE: order of covariate inclusion -> avoiding stepwise a pproaches -> abandoning exploratory analysis?
technical
|
| Oct 22, 2003 |
Re: LLR test, AIC, BIC
technical
|
| Oct 29, 2003 |
Re: lagged concentrations
technical
|
| Oct 30, 2003 |
Re: lagged concentrations
technical
|
| Nov 17, 2003 |
Re: Different population estimates
technical
|
| Nov 17, 2003 |
Re: Different population estimates
technical
|
| Nov 17, 2003 |
Re: Different population estimates
technical
|
| Dec 05, 2003 |
Re: BOV Code
technical
|
| Dec 17, 2003 |
Re: Nonmem model
technical
|
| Dec 19, 2003 |
Re: Nonmem model
technical
|
| Jan 13, 2004 |
Re: Fixed elements within a block covariance matrix
technical
|
| Jan 14, 2004 |
Re: Fixed elements within a block covariance matrix
technical
|
| Feb 05, 2004 |
RE: Simulation problems
technical
|
| Feb 10, 2004 |
RE: Simulated vs. fitted population concentration curves
technical
|
| Feb 12, 2004 |
Re: Fortran overflow
technical
|
| Feb 17, 2004 |
Re: Implementation of interindividual variability in residual variance
technical
|
| Feb 18, 2004 |
Re: Implementation of interindividual variability in residual variance
technical
|
| Apr 29, 2004 |
RE: Trouble increasing ETA capacity in NMV 1.1
technical
|
| May 18, 2004 |
RE: problem with acquiring post hoc estimates
technical
|
| May 18, 2004 |
RE: problem with acquiring post hoc estimates
technical
|
| May 21, 2004 |
RE: Constant and Proportional Error with Log transformed data with single data point per subject
technical
|
| Jun 01, 2004 |
RE: $OMEGA blocks and log-likelihood profiling
technical
|
| Jun 08, 2004 |
RE: $OMEGA blocks and log-likelihood profiling
technical
|
| Jun 10, 2004 |
RE: How sparse is too sparse?
technical
|
| Jun 10, 2004 |
RE: $OMEGA blocks and log-likelihood profiling
technical
|
| Jun 10, 2004 |
RE: $OMEGA blocks and log-likelihood profiling
technical
|
| Jun 16, 2004 |
RE: Renal CL estimations
technical
|
| Jun 24, 2004 |
RE: protein binding
technical
|
| Jun 24, 2004 |
RE: protein binding
technical
|
| Aug 06, 2004 |
RE: Changing Clearance over time : Enzyme auto-induction
technical
|
| Aug 23, 2004 |
RE: Decrease in OFV with a fixed effect
technical
|
| Sep 16, 2004 |
RE: covariates
technical
|
| Sep 17, 2004 |
RE: covariates
technical
|
| Sep 17, 2004 |
RE: covariates
technical
|
| Sep 17, 2004 |
RE: covariates
technical
|
| Sep 20, 2004 |
RE: covariates
technical
|
| Nov 19, 2004 |
RE: NONMEM Bug Overview - AAPS
technical
|
| Nov 26, 2004 |
RE: Permutation test with small number of possible permutations
technical
|
| Nov 27, 2004 |
RE: Permutation test with small number of possible permutations
technical
|
| Nov 29, 2004 |
RE: Determining metabolite clearance fraction
technical
|
| Dec 08, 2004 |
RE: posthoc step
technical
|
| Dec 08, 2004 |
RE: SAS program or SAS macro to prepare NonMem ready data
technical
|
| Dec 11, 2004 |
RE: SAS program or SAS macro to prepare NonMem ready data
technical
|
| Mar 15, 2005 |
Re: Modeling of different formulations
technical
|
| Apr 04, 2005 |
Re: population size and confidence power
technical
|
| Apr 15, 2005 |
RE: simulation of dose escalation study
technical
|
| Apr 20, 2005 |
Re: addition of dummy points
technical
|
| Apr 21, 2005 |
Re: addition of dummy points
technical
|
| Apr 21, 2005 |
Re: addition of dummy points
technical
|
| Apr 22, 2005 |
Re: addition of dummy points
technical
|
| Apr 27, 2005 |
Re: Model building advice
technical
|
| May 13, 2005 |
Probabilistic model
technical
|
| May 13, 2005 |
Re: Probabilistic model
technical
|
| May 17, 2005 |
Re: Probabilistic model
technical
|
| May 19, 2005 |
Re: Follow up: Model building advice
technical
|
| May 27, 2005 |
RES and WRES
technical
|
| Jun 25, 2005 |
Re: NONMEM Tips #22 - June 20, 2005 - Upgrading to Intel9.0 Fortran for Windows
technical
|
| Jun 29, 2005 |
Re: POSTHOC and ETA values disagree
technical
|
| Jul 01, 2005 |
Re: POSTHOC and ETA values disagree
technical
|
| Jul 17, 2005 |
Re: End of semester MCQ and short answer question
technical
|
| Jul 17, 2005 |
Re: End of semester MCQ and short answer question
technical
|
| Jul 26, 2005 |
Re: log transformed data and multi compartment PK
technical
|
| Aug 03, 2005 |
RE: Standard errors below 0.1%?
technical
|
| Sep 23, 2005 |
Dose and concentration unit differences
technical
|
| Oct 06, 2005 |
Re: non-linear PK
technical
|
| Oct 06, 2005 |
Re: non-linear PK
technical
|
| Oct 19, 2005 |
Re: Inclusion of covariates and model improvement
technical
|
| Oct 20, 2005 |
Re: Inclusion of covariates and model improvement
technical
|
| Oct 28, 2005 |
Re: target-mediated model - steady state - unstable system?
technical
|
| Nov 16, 2005 |
Re: Incorporating duplicate assays
technical
|
| Jan 20, 2006 |
RE: covariate selection question
technical
|
| Mar 28, 2006 |
Re: restraining eta code
event
|
| Mar 28, 2006 |
Re: restraining eta code
event
|
| May 02, 2006 |
Re: leverage analysis vs. case deletion
technical
|
| Jun 26, 2006 |
logistic regression: NONMEM LAPLACIAN vs. Gaussian quadrature
technical
|
| Jun 26, 2006 |
Re: logistic regression: NONMEM LAPLACIAN vs. Gaussian quadrature
technical
|
| Jun 26, 2006 |
Re: logistic regression: NONMEM LAPLACIAN vs. Gaussian quadrature
technical
|
| Jul 30, 2006 |
Re: Problems with an apparent compiler-senstive model
technical
|
| Aug 02, 2006 |
Re: Problems with an apparent compiler-senstive model
technical
|
| Aug 02, 2006 |
Re: Problems with an apparent compiler-senstive model
technical
|
| Aug 02, 2006 |
RE: Error when combining proportional residual error,
technical
|
| Aug 02, 2006 |
RE: Error when combining proportional residual error,
technical
|
| Sep 08, 2006 |
Re: importData in S as numeric format
technical
|
| Sep 22, 2006 |
Re: Bootstrap question
technical
|
| Sep 26, 2006 |
RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
technical
|
| Sep 26, 2006 |
RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION
technical
|
| Feb 12, 2007 |
Re: Problems with a physiologic model
technical
|
| Feb 20, 2007 |
ETABAR p-value
technical
|
| Feb 28, 2007 |
Re: Best approach with limited data
technical
|
| Mar 04, 2007 |
Re: parent drug and metabolite
technical
|
| Mar 05, 2007 |
Re: parent drug and metabolite
technical
|
| Mar 08, 2007 |
Re: Antwort: Re: change from mass to molar units
technical
|
| May 07, 2007 |
Re: Improved absorption profile by forcing volume of the
central compartment
technical
|
| May 07, 2007 |
Re: Improved absorption profile by forcing volume of the central compartment
technical
|
| May 29, 2007 |
Re: trough time same as dosing time
technical
|
| Jun 06, 2007 |
Re: How does TIME work for multiple doses in NONMEM?
technical
|
| Jun 25, 2007 |
Re: tumor growth model
technical
|
| Jul 09, 2007 |
Re: Query on model development
technical
|
| Jul 24, 2007 |
Re: Nonparametric method
technical
|
| Jul 30, 2007 |
Re: $MIX and $CONTR
technical
|
| Jul 31, 2007 |
Re: $MIX and $CONTR
technical
|
| Sep 13, 2007 |
Re: S-plus multivariate normal distribution
technical
|
| Sep 21, 2007 |
Re: SIMULATION QUESTIONS
technical
|
| Sep 26, 2007 |
Re: Data File
technical
|
| Sep 27, 2007 |
Re: bug/feature in $AES
technical
|
| Sep 28, 2007 |
Re: bug/feature in $AES
technical
|
| Oct 05, 2007 |
Re: Error model
technical
|
| Oct 12, 2007 |
Re: permissible band matrix
technical
|
| Oct 15, 2007 |
Re: different COMRES statements
technical
|
| Oct 24, 2007 |
Re: Reporting Modeling Results
technical
|
| Oct 25, 2007 |
Re: Reporting Modeling Results
technical
|
| Oct 26, 2007 |
Re: Reporting Modeling Results
technical
|
| Oct 26, 2007 |
Re: R package useful for electronic regulatory submissions
news
|
| Oct 29, 2007 |
Re: help with modelling of categorical response data
technical
|
| Dec 07, 2007 |
Re: Unix to Windows Model Translation / PK Comp Initialization
technical
|
| Dec 12, 2007 |
Re: Cmax, Tmax, and Time and AUC above threshold such as MIC
technical
|
| Jan 15, 2008 |
Re: Multiple amniotic fluid samples
technical
|
| Jan 15, 2008 |
Re: "Connect the dots" approach for a time-varying covariate
technical
|
| Jan 29, 2008 |
Re: Why does covariance fail?
technical
|
| Feb 06, 2008 |
Re: output SE of population PK parameters in Nonmem
technical
|
| Feb 14, 2008 |
Re: Combined residual model and IWRES.
technical
|
| Feb 15, 2008 |
Re: IIV on %CV-Scale - Standard Error (SE)
technical
|
| Feb 27, 2008 |
Re: System call from R causes loss of cursor control
technical
|
| Apr 09, 2008 |
Re: NM VI and NMV gave different results
technical
|
| Apr 21, 2008 |
Re: Number of bootstrap runs needed for confidence intervals
technical
|
| Apr 22, 2008 |
Re: truncation & simulation
technical
|
| Apr 24, 2008 |
Re: Body weight distribution
technical
|
| May 01, 2008 |
Re: Differences with ADVAN3 TRANS1 and ADVAN3 TRANS4
technical
|
| May 23, 2008 |
Re: Visual predictive check!
technical
|
| May 28, 2008 |
Re: Sparse (pediatric) and rich (adult) data
technical
|
| May 29, 2008 |
Re: Sparse (pediatric) and rich (adult) data
technical
|
| Jun 30, 2008 |
Re: iNTRAVENOUS VS. INTRA-ARTERIAL SAMPLING
technical
|
| Jul 03, 2008 |
Re: Estimation of standard error
technical
|
| Jul 19, 2008 |
Re: algorithm limits
technical
|
| Jul 20, 2008 |
Re: algorithm limits
technical
|
| Jul 25, 2008 |
Re: problem with PK fit in a PKPD model
technical
|
| Jul 25, 2008 |
Re: FW: PPC
technical
|
| Jul 26, 2008 |
Re: problem with PK fit in a PKPD model
technical
|
| Sep 07, 2008 |
NONMEM memory vs. run time
technical
|
| Sep 08, 2008 |
NONMEM memory vs. run time
technical
|
| Sep 19, 2008 |
Re: Scaling for pediatric study planning
technical
|
| Sep 19, 2008 |
Re: target-mediate model: numerical difficulties
technical
|
| Sep 29, 2008 |
Re: a potential bug
technical
|
| Oct 16, 2008 |
Re: More Levels of Random Effects
technical
|
| Oct 17, 2008 |
Re: More Levels of Random Effects
technical
|
| Oct 22, 2008 |
Re: More Levels of Random Effects
technical
|
| Nov 13, 2008 |
Re: Very small P-Value for ETABAR
technical
|
| Nov 14, 2008 |
Re: Very small P-Value for ETABAR
technical
|
| Nov 18, 2008 |
RE: Models that abort before convergence
technical
|
| Nov 20, 2008 |
Re: Models that abort before convergence Addendum
technical
|
| Nov 21, 2008 |
Re: Models that abort before convergence Addendum
technical
|
| Dec 03, 2008 |
unscientific poll
technical
|
| Dec 09, 2008 |
Re: Modelling intracellular and plasma data
technical
|
| Dec 09, 2008 |
Re: FO vs FOCE, sequential vs simultaneous
technical
|
| Jan 12, 2009 |
Re: CrcL or Cr in pediatric model
technical
|
| Jan 13, 2009 |
Re: CrcL or Cr in pediatric model
technical
|
| Jan 14, 2009 |
Re: CrcL or Cr in pediatric model
technical
|
| Feb 02, 2009 |
Re: Identifiablity of parent / metabolite PK with interconversion
technical
|
| Feb 03, 2009 |
Re: Identifiablity of parent / metabolite PK with interconversion
technical
|
| Feb 04, 2009 |
Re: Identifiablity of parent / metabolite PK with interconversion
technical
|
| Feb 05, 2009 |
Re: simulation question
technical
|
| Feb 06, 2009 |
Re: simulation question
technical
|
| Feb 13, 2009 |
Re: Theoretical questions about Beal's M2 method
technical
|
| Feb 24, 2009 |
Re: var-cov matrix issue?
technical
|
| Feb 25, 2009 |
Re: VPC, NPC or PPC?
technical
|
| Feb 26, 2009 |
Re: VPC, NPC or PPC?
technical
|
| Mar 26, 2009 |
Re: Log transformation of concentration
technical
|
| Apr 14, 2009 |
Re: OMEGA BLOCK with mixture model?
technical
|
| Apr 14, 2009 |
Re: VPC with Mixture Model
technical
|
| Apr 16, 2009 |
Re: OMEGA BLOCK with mixture model?
technical
|
| Apr 19, 2009 |
Re: OMEGA BLOCK with mixture model?
technical
|
| Apr 21, 2009 |
Re: Bootstrap analysis
technical
|
| Apr 23, 2009 |
Re: Resetting af single compartment
technical
|
| Jun 02, 2009 |
Re: forrtl: error (73): floating divide by zero
technical
|
| Jun 03, 2009 |
Re: forrtl: error (73): floating divide by zero
technical
|
| Jun 04, 2009 |
Re: Coding a triple absorption model
technical
|
| Jun 09, 2009 |
Re: Time to event analysis using NONMEM
technical
|
| Jun 17, 2009 |
Re: estimating Ka from dataset combining rich sample study
and sparse sampling study
technical
|
| Jun 17, 2009 |
Re: estimating Ka from dataset combining rich sample study and sparse sampling study
technical
|
| Jun 29, 2009 |
Re: Problem with HESSIAN
technical
|
| Aug 03, 2009 |
Re: OMEGA-Block
technical
|
| Aug 04, 2009 |
Re: OMEGA-Block
technical
|
| Aug 04, 2009 |
Re: COND LAPLACE LIKELIHOOD
technical
|
| Aug 07, 2009 |
Re: Code to avoid flip-flop kinetics
technical
|
| Aug 10, 2009 |
Re: Code to avoid flip-flop kinetics
technical
|
| Aug 11, 2009 |
Re: Code to avoid flip-flop kinetics
technical
|
| Aug 21, 2009 |
Re: Linear VS LTBS
technical
|
| Aug 24, 2009 |
Re: What does convergence/covariance show?
technical
|
| Aug 25, 2009 |
Re: What does convergence/covariance show?
technical
|
| Sep 18, 2009 |
Re: VPC appropriateness in complex PK
technical
|
| Sep 19, 2009 |
Re: VPC appropriateness in complex PK
technical
|
| Sep 20, 2009 |
Re: VPC appropriateness in complex PK
technical
|
| Oct 02, 2009 |
Re: PD modelling problem - Emax at lower bound?
technical
|
| Oct 08, 2009 |
Re: Missing value when modeling categorical data
technical
|
| Oct 16, 2009 |
Re: The system cannot execute the specified program
technical
|
| Nov 05, 2009 |
Re: FW: advan8 vs. advan13 (CORRECTION)
technical
|
| Nov 18, 2009 |
Re: Modeling biomarker data below the LOQ
technical
|
| Nov 19, 2009 |
Re: Modeling biomarker data below the LOQ
technical
|
| Nov 20, 2009 |
Re: Modeling biomarker data below the LOQ
technical
|
| Nov 23, 2009 |
R/S+ nlme ODE
technical
|
| Dec 04, 2009 |
Re: Model building
technical
|
| Dec 11, 2009 |
Re: Duration of Absorption Time From Depot (Gut) as Covariate
technical
|
| Dec 15, 2009 |
Re: $ERROR and LOGIT
technical
|
| Dec 15, 2009 |
Re: Duration of Absorption Time From Depot (Gut) as Covariate
technical
|
| Dec 16, 2009 |
Re: Duration of Absorption Time From Depot (Gut) as Covariate
technical
|
| Jan 21, 2010 |
Re: missing table file
technical
|
| Feb 10, 2010 |
Re: Sequential PK PD
technical
|
| Feb 14, 2010 |
Re: computational issues preventing COV
technical
|
| Feb 18, 2010 |
Re: Predict AUC based on trough concentrations
technical
|
| Feb 24, 2010 |
Re: Meta-analysis with Nonmem
technical
|
| Feb 26, 2010 |
Re: Meta-analysis with Nonmem
technical
|
| Mar 26, 2010 |
Re: scaling problem??
technical
|
| Mar 28, 2010 |
Re: Parallel first order and Michaelis-Menten elimination
technical
|
| Mar 30, 2010 |
Re: Parallel first order and Michaelis-Menten elimination
technical
|
| Mar 31, 2010 |
Error model
technical
|
| Apr 06, 2010 |
Re: Generating Cmax at end of infusion
technical
|
| Apr 07, 2010 |
Re: Generating Cmax at end of infusion
technical
|
| Apr 24, 2010 |
Re: Weibull Absorption Simulation - Multiple Doses
technical
|
| Apr 25, 2010 |
Re: Weibull Absorption Simulation - Multiple Doses
technical
|
| May 12, 2010 |
Re: nm7 IMP method question
technical
|
| May 31, 2010 |
Re: distribution assumption of Eta in NONMEM
technical
|
| Jun 27, 2010 |
Re: Comaprison of two models
technical
|
| Aug 11, 2010 |
Re: Rounding errors with TRANSIT model
technical
|
| Aug 11, 2010 |
Re: Baseline as a covariate
technical
|
| Aug 17, 2010 |
Re: Issue with Volume of Peripheral Comp
technical
|
| Aug 29, 2010 |
Re: Trial optimization across multiple endpoints
technical
|
| Aug 30, 2010 |
Re: FW: Block versus diagonal omega
technical
|
| Aug 31, 2010 |
Re: FW: Block versus diagonal omega
technical
|
| Sep 01, 2010 |
Re: $PK ADVAN6
technical
|
| Sep 06, 2010 |
Re: How serious are negative eigenvalues?
technical
|
| Sep 07, 2010 |
Re: Negative eigenvalues, over-paramterization, finding most sensitive parameter
technical
|
| Sep 20, 2010 |
bug list
news
|
| Oct 08, 2010 |
Re: Very big NONMEM
technical
|
| Nov 01, 2010 |
Re: Hessian of posterior density is non positive definite during search
technical
|
| Nov 23, 2010 |
Re: Predictions beyond SS dosing time + II
technical
|
| Nov 24, 2010 |
Re: RE: Zähneputzen VOR oder NACH dem Frühstück? What comes fir st? BSV, BOV, or covariates?
technical
|
| Jan 06, 2011 |
Re: outsourcing PK/PD analysis - help wanted
job
|
| Jan 26, 2011 |
Re: High spec PC setup for NONMEM - recommendations?
technical
|
| Feb 03, 2011 |
Re: Inclusion of Analytical Expressions in NONMEM control file
technical
|
| Feb 12, 2011 |
Re: Problems with PD Modelling
technical
|
| Feb 13, 2011 |
Re: Problems with PD Modelling
technical
|
| Apr 11, 2011 |
Re: Modeling Cmin and Tmin
technical
|
| May 23, 2011 |
simulation problem or bug
technical
|
| May 24, 2011 |
Re: simulation problem or bug
technical
|
| May 25, 2011 |
Re: simulation problem or bug
technical
|
| Jun 02, 2011 |
Re: Modeling concentration data with imprecise sampling time
technical
|
| Jun 03, 2011 |
Re: Modeling concentration data with imprecise sampling time
technical
|
| Jul 10, 2011 |
Re: Confidence intervals of PsN bootstrap output
technical
|
| Jul 11, 2011 |
Re: Confidence intervals of PsN bootstrap output
technical
|
| Jul 22, 2011 |
Re: inverse gaussian input function
technical
|
| Jul 28, 2011 |
Re: Self-abort/protective code for bootstrapping
technical
|
| Jul 28, 2011 |
Re: lagged absorption and empirical input function
technical
|
| Sep 21, 2011 |
Re: analysis of non-positive DV
technical
|
| Sep 22, 2011 |
Re: Epsilon shrinkage and IWRES
technical
|
| Oct 14, 2011 |
Re: PRIOR method without covariance matrix of estimates?
technical
|
| Oct 15, 2011 |
Re: PRIOR method without covariance matrix of estimates?
technical
|
| Oct 28, 2011 |
Re: Delayd Cmax following infusion of a monoclonal antibody
technical
|
| Nov 14, 2011 |
Re: CycleCloud BigScience Challenge giving away ~8-hours on 30000 core cluster for research
technical
|
| Dec 12, 2011 |
Re: Different assays for different studies
technical
|
| Dec 22, 2011 |
Re: Bootstrap in combination with PRIOR?
technical
|
| Jan 13, 2012 |
Re: Fwd: Re: Predicting Drug in Tissue A2 using MAXEVAL=0
technical
|
| Jan 14, 2012 |
Re: Memory problems with Xpose
technical
|
| Feb 03, 2012 |
Re: Output EPS(1) after an $EST step?
technical
|
| Feb 13, 2012 |
Re: NONLINEAR PK MODEL ERROR
technical
|
| Mar 15, 2012 |
Re: NONMEM compiler
technical
|
| Apr 11, 2012 |
Re: Parallel first order and Michaelis-Menten elimination
technical
|
| Apr 25, 2012 |
Re: modeling of total concentration of two drugs with different kinetics in NONMEM
technical
|
| May 10, 2012 |
Re: VPC results using PsN and Xpose
technical
|
| May 25, 2012 |
Re: Question about handling BLOQ data with mixture model
technical
|
| Jun 22, 2012 |
Re: different parameterizations of OMEGA matrix vs. chance
of getting flip-flop estimates
technical
|
| Jun 22, 2012 |
Re: different parameterizations of OMEGA matrix vs. chance of getting flip-flop estimates
technical
|
| Jul 05, 2012 |
Re: Time after dose
technical
|
| Jul 05, 2012 |
Re: Log transformation of both sides
technical
|
| Jul 06, 2012 |
Re: Modeling targeted mediated drug disposition using Quasi-equilibrium model
job
|
| Aug 14, 2012 |
Re: restart NONMEM
technical
|
| Nov 23, 2012 |
Re: Different EBE estimation between original and enriched dataset with MDV=1
technical
|
| Nov 26, 2012 |
Re: Different EBE estimation between original and enriched dataset with MDV=1
technical
|
| Nov 27, 2012 |
Re: Different EBE estimation between original and enriched dataset with MDV=1
technical
|
| Dec 15, 2012 |
Re: capecitabine PopPK
technical
|
| Jan 08, 2013 |
MPI question
technical
|
| Jan 09, 2013 |
Re: Minimisation problem...
technical
|
| Jan 18, 2013 |
Re: how to model blood volume change during and after hemodialysis?
technical
|
| Feb 12, 2013 |
Re: Additive residual error
technical
|
| Feb 18, 2013 |
Re: Simulation settgin in the precence of Shrinkage in PK when doing PK-PD analysis
technical
|
| Feb 19, 2013 |
Re: RE: Simulation settgin in the precence of Shrinkage in PK when doing PK-PD analysis
technical
|
| Mar 07, 2013 |
QuantPharm workshops for 2013
event
|
| Mar 29, 2013 |
Re: ACoP 2013 - Don't Dilly Dally
event
|
| Apr 03, 2013 |
Re: seeking help on NONMEM code for simulation of Repeated Time to Event Data
technical
|
| Apr 04, 2013 |
Re: seeking help on NONMEM code for simulation of Repeated Time to Event Data
technical
|
| Apr 10, 2013 |
PAGE Satellite Workshop: Modeling Biologics with Target-Mediated Disposition
event
|
| May 07, 2013 |
Re: Mixture model simulation
technical
|
| May 26, 2013 |
Re: MU referencing
technical
|
| Jul 24, 2013 |
Re: PKPD-simulations
technical
|
| Jul 25, 2013 |
Re: if-the-statement for 3 class categorical covariate
technical
|
| Aug 12, 2013 |
Re: Reducing ETAs actually decreased OFV
technical
|
| Aug 12, 2013 |
Workshop on PK and PD Modeling Biologics in Baltimore, MD
event
|
| Aug 25, 2013 |
Re: Reducing ETAs actually decreased OFV
technical
|
| Aug 26, 2013 |
Re: Reducing ETAs actually decreased OFV
technical
|
| Aug 26, 2013 |
Workshop on PK and PD Modeling Biologics in Baltimore, MD
event
|
| Sep 16, 2013 |
Re: Covariate model building with SAEM andIMP
technical
|
| Sep 19, 2013 |
Re: Parameter Estimation in IF Conditioning Statement
technical
|
| Sep 19, 2013 |
Re: AW: Re: Parameter Estimation in IF Conditioning Statement
technical
|
| Sep 20, 2013 |
Re: AW: Re: Parameter Estimation in IF Conditioning Statement
technical
|
| Oct 08, 2013 |
Re: Change of NSIG or R matrix
technical
|
| Oct 08, 2013 |
Re: Simulations with OMEGA BLOCK
technical
|
| Oct 08, 2013 |
Re: PopED and SSE comparison
technical
|
| Oct 17, 2013 |
Re: IV and SC injection
technical
|
| Oct 22, 2013 |
Re: Change of NSIG or R matrix
technical
|
| Nov 03, 2013 |
Re: 2 cmax after a single SC dose
technical
|
| Nov 22, 2013 |
Re: Getting rid of correlation issues between CL and volume
parameters
technical
|
| Nov 22, 2013 |
Re: Getting rid of correlation issues between CL and volume parameters
technical
|
| Nov 26, 2013 |
Re: Getting rid of correlation issues between CL and volume parameters
technical
|
| Jan 05, 2014 |
Re: Question: FO VS. FOCE VS. FOCE-INTER in POSTHOC 2014-1-3
technical
|
| Jan 06, 2014 |
Re: Question: FO VS. FOCE VS. FOCE-INTER in POSTHOC 2014-1-3
technical
|
| Feb 17, 2014 |
Re: integrated parent-metabolite PK model from sequential iv and oral doses of parent drug
technical
|
| Mar 05, 2014 |
Modeling of Biologics/Nonmem workshops April 8-11
event
|
| Mar 21, 2014 |
Re: Weighting observations
technical
|
| Jul 11, 2014 |
Parallel Nonmem of Intel Xeon Phi Coprocessor
technical
|
| Aug 26, 2014 |
Re: [mixture models] assign individual to a subpopulation every dosing record?
technical
|
| Aug 27, 2014 |
Re: [mixture models] assign individual to a subpopulation every dosing record?
technical
|
| Sep 04, 2014 |
Re: Inflated random effects showed by VPC
technical
|
| Sep 08, 2014 |
parallel computing
technical
|
| Sep 09, 2014 |
Re: parallel computing
technical
|
| Nov 19, 2014 |
Re: Genotype data missing in some individuals
technical
|
| Feb 06, 2015 |
Re: Choosing variabilities
technical
|
| Feb 12, 2015 |
Re: RE: Standard errors of estimates for strictly positive
parameters
technical
|
| Feb 12, 2015 |
Re: RE: Standard errors of estimates for strictly positive parameters
technical
|
| Mar 31, 2015 |
Re: Turning off IEEE floating point messages for new gfortran
compilers
technical
|
| Mar 31, 2015 |
Re: Turning off IEEE floating point messages for new gfortran compilers
technical
|
| Apr 20, 2015 |
Re: variation of time values in output data
technical
|
| Jun 12, 2015 |
Re: Population PKPD using hair drug concentration
technical
|
| Jun 21, 2015 |
Modeling of Biologics Workshops: October 8, 2015 (at ACoP-6)
event
|
| Jun 23, 2015 |
Re: Simulo: a new service for drug trial simulation
technical
|
| Jul 03, 2015 |
Re: Zeros in OMEGA matrix
technical
|
| Jul 27, 2015 |
Re: Is it reasonable to add covarite to PD parameters kin
or kout?
technical
|
| Jul 27, 2015 |
Re: Is it reasonable to add covarite to PD parameters kin or kout?
technical
|
| Aug 24, 2015 |
TMDD Workshop at ACOP-2015
event
|
| Sep 05, 2015 |
Re: RE: Estimation of ke0 from raw data
technical
|
| Sep 08, 2015 |
Re: Is �DOSE=0� accepted by NONMEM?
technical
|
| Sep 08, 2015 |
Re: Is “DOSE=0” accepted by NONMEM?
technical
|
| Sep 10, 2015 |
Re: FW: Question of fitting population PK model using
summary statistics of data instead of raw data
technical
|
| Sep 10, 2015 |
Re: FW: Question of fitting population PK model using summary statistics of data instead of raw data
technical
|
| Sep 11, 2015 |
Re: FW: FW: Question of fitting population PK model using
summary statistics of data instead of raw data
technical
|
| Sep 11, 2015 |
Re: FW: FW: Question of fitting population PK model using summary statistics of data instead of raw data
technical
|
| Sep 23, 2015 |
Re: Imputation of multiple categorical covariates with
missing data
technical
|
| Sep 23, 2015 |
Re: Imputation of multiple categorical covariates with missing data
technical
|
| Sep 27, 2015 |
Re: Error in table step
technical
|
| Oct 29, 2015 |
Re: NM-Tran infer data are single subject when perform
simulation
technical
|
| Oct 29, 2015 |
Re: NM-Tran infer data are single subject when perform simulation
technical
|
| Nov 06, 2015 |
Box-Cox tranformation
technical
|
| Nov 21, 2015 |
Re: PRED for BLQ-like observations
technical
|
| Dec 10, 2015 |
Re: Error in LSODA: Code -5
technical
|
| Dec 10, 2015 |
Re: Confidence interval calculations
technical
|
| Dec 11, 2015 |
Re: Error in LSODA: Code -5
technical
|
| Dec 13, 2015 |
West Coast Workshop: Modeling Biologics with Target-Mediated
Disposition
event
|
| Dec 13, 2015 |
West Coast Workshop: Modeling Biologics with Target-Mediated Disposition
event
|
| Dec 22, 2015 |
Re: Problem of STS in NONMEM
technical
|
| Jan 06, 2016 |
Re: unbalanced data set
technical
|
| Feb 03, 2016 |
Workshop on modeling of biologics: first time in the Bay Area (SFO)
event
|
| Apr 22, 2016 |
Re: Rounding (error=134) or obj. func. is infinite (error=136)
technical
|
| Apr 23, 2016 |
Re: Rounding (error=134) or obj. func. is infinite (error=136)
technical
|
| Jun 02, 2016 |
Re: Additive plus proportional error model for
log-transform data
technical
|
| Jun 02, 2016 |
Re: Additive plus proportional error model for log-transform data
technical
|
| Sep 02, 2016 |
Re: Simultaneous pk model of 2 drugs
technical
|
| Sep 19, 2016 |
Re: IMP and parallelisation
technical
|
| Sep 20, 2016 |
Re: AW: IMP and parallelisation
technical
|
| Sep 27, 2016 |
Re: residual variability
technical
|
| Sep 29, 2016 |
Re: residual variability
technical
|
| Jan 05, 2017 |
Re: A problem with numerical integration difficulties for a
complex model
technical
|
| Jan 05, 2017 |
Re: A problem with numerical integration difficulties for a complex model
technical
|
| Jan 16, 2017 |
Re: Objective function
technical
|
| Feb 15, 2017 |
Re: FW: Parameter uncertainty
technical
|
| Mar 09, 2017 |
Re: RE: question about random seed for simulation
technical
|
| Apr 24, 2017 |
Re: Modelling IV and IP simultaneously
technical
|
| Jul 31, 2017 |
Intel AVX and AVX2 set of instructions for compiling Nonmem
technical
|
| Aug 24, 2017 |
Re: Use of ACCEPT in $DATA
technical
|
| Dec 19, 2017 |
West Coast Workshop: Modeling Biologics with Target-Mediated
Disposition
event
|
| Dec 19, 2017 |
West Coast Workshop: Modeling Biologics with Target-Mediated Disposition
event
|
| Dec 20, 2017 |
Re: Numerical integreaion and change in clearance over time
technical
|
| Jan 23, 2018 |
Re: CMT Remapping
technical
|
| Feb 02, 2018 |
Re: unidentified cause of "F OR DERIVATIVE RETURNED BY PRED
IS INFINITE (INF) OR NOT A NUMBER (NAN)"
technical
|
| Feb 02, 2018 |
Re: unidentified cause of "F OR DERIVATIVE RETURNED BY PRED IS INFINITE (INF) OR NOT A NUMBER (NAN)"
technical
|
| Mar 14, 2018 |
Re: Time-Varying Bioavailability on Zero-Order Infusion
technical
|
| Apr 06, 2018 |
Re: ETAs & SIGMA in external validation
technical
|
| May 03, 2018 |
Cmax/Tmax in the DES block
technical
|
| May 04, 2018 |
Cmax/Tmax in the DES block
technical
|
| May 05, 2018 |
Re: Cmax/Tmax in the DES block
technical
|
| Jul 10, 2018 |
East Coast Workshop: Modeling Biologics with Target-Mediated
Disposition, September 14th 2018
event
|
| Jul 10, 2018 |
East Coast Workshop: Modeling Biologics with Target-Mediated Disposition, September 14th 2018
event
|
| Aug 23, 2018 |
Re: IMPMAP behavior question
technical
|
| Oct 01, 2018 |
Re: NONMEM 2 Compartment Zero Order Absorption
technical
|
| Nov 16, 2018 |
Re: $ERROR block TMDD
technical
|
| Nov 20, 2018 |
Re: Potential bug in NM 7.3 and 7.4.2
technical
|
| Nov 21, 2018 |
Re: Potential bug in NM 7.3 and 7.4.2
technical
|
| Feb 04, 2019 |
Re: Why should we avoid using micro rate constants?
technical
|
| Feb 13, 2019 |
Re: OFV or Diagnostic Plot ?? Which one rules...
technical
|
| Feb 22, 2019 |
Re: Strange PRED prediction in SAEM with M3 BQL handling
technical
|
| Mar 05, 2019 |
Re: SAEM with MAXEVAL= 0 possible? or any work around?
technical
|
| Apr 22, 2019 |
Re: Simulation error
technical
|
| Apr 23, 2019 |
Re: Help with a PK code
technical
|
| Jul 31, 2019 |
Re: ERROR NUMBER OF BASIC PK PARAMETERS EXCEEDS VALUE OF
NPARAM IN $MODEL
technical
|
| Jul 31, 2019 |
Re: ERROR NUMBER OF BASIC PK PARAMETERS EXCEEDS VALUE OF NPARAM IN $MODEL
technical
|
| Aug 01, 2019 |
Re: $ERROR block for feedback mechanism
technical
|
| Aug 13, 2019 |
Re: NONMEM Unexpected result with the $LEVEL statement
technical
|
| Sep 28, 2019 |
Re: Is there an easy way to get PRED from NONMEM when
objective function instead of error model is specified?
technical
|
| Sep 28, 2019 |
Re: Is there an easy way to get PRED from NONMEM when objective function instead of error model is specified?
technical
|
| Oct 24, 2019 |
Re: Algebraic equations and IOV
technical
|
| Oct 29, 2019 |
Re: RE: Stepwise covariate modeling
technical
|
| Nov 08, 2019 |
Re: cumulative AUC
technical
|
| Nov 18, 2019 |
AMD vs Intel
technical
|
| Nov 19, 2019 |
Re: AMD vs Intel
technical
|
| Nov 20, 2019 |
Re: AMD vs Intel
technical
|
| Dec 08, 2019 |
Re: Final Parameter is same as initial parameter - integrated PK-PD models with two PD parameters
technical
|
| Feb 11, 2020 |
Re: Time-varying bioavailability and reproducibility in NONMEM analysis
technical
|
| Feb 12, 2020 |
Re: Time-varying bioavailability and reproducibility in NONMEM analysis
technical
|
| Jun 02, 2020 |
Re: Negative concentration from simulation
technical
|
| Aug 05, 2020 |
Re: Variability on infusion duration
technical
|
| Aug 12, 2020 |
Re: Random effect on ALAG between dose events
technical
|
| Sep 23, 2020 |
Re: OFV from different algorithms
technical
|
| Sep 24, 2020 |
Re: OFV from different algorithms
technical
|
| Dec 15, 2020 |
Re: Variability in Dosing Rate (and amount)
technical
|
| Feb 12, 2021 |
Re: Two way crossover
technical
|
| Apr 28, 2021 |
Re: Assessment of elimination half life of mAb
technical
|
| Apr 29, 2021 |
Re: Assessment of elimination half life of mAb
technical
|
| Jul 19, 2021 |
Re: computation of exponential error model for RUV
technical
|
| Jul 22, 2021 |
Re: Help with ODEs for a time varying clearance
technical
|
| Aug 06, 2021 |
Re: Time-varying input/flexibility to change input rate on
the fly
technical
|
| Aug 06, 2021 |
Re: Time-varying input/flexibility to change input rate on the fly
technical
|
| Jul 17, 2022 |
unofficial survey: COVID at PAGE
event
|
| Jul 24, 2022 |
Update for unofficial survey: COVID at PAGE
event
|
| Aug 01, 2022 |
Final count for unofficial survey: COVID at PAGE
event
|
| Aug 17, 2022 |
Re: Problems when implementing M3 for BLQs
technical
|
| Sep 13, 2022 |
Re: flip-flop without absorption information?
technical
|
| Sep 16, 2022 |
Continuation of "What does "Second Error signal from LINV1PD: 129"
technical
|
| Sep 17, 2022 |
Re: [EXTERNAL] Continuation of "What does "Second Error signal from LINV1PD: 129"
technical
|
| Nov 30, 2022 |
Re: Condition number
technical
|
| Dec 17, 2022 |
Re: Simulate with parameter uncertainty
technical
|
| Dec 20, 2022 |
Re: Off diagonals in $TABLE
technical
|
| Jan 04, 2023 |
Re: Modeling for non-Normal distributions of individual parameters
technical
|
| May 26, 2023 |
Re: Problem with estimating sigma when using M3 method
technical
|
| May 30, 2023 |
Re: Problem with estimating sigma when using M3 method
technical
|
| May 31, 2023 |
Re: Problem with estimating sigma when using M3 method
technical
|
| Jun 19, 2023 |
Re: BQL simulations
technical
|
| Jul 06, 2023 |
Re: Specify full OMEGA matrix for simulation
technical
|
| Oct 09, 2023 |
Re: Simulate with ETAs from .phi and residual variability
technical
|
| Jan 26, 2024 |
Re: NONMEM Error on SAEM but not FOCEI
technical
|
| Mar 05, 2024 |
Re: Warning obtained while running SAEM
technical
|
| Mar 24, 2024 |
Re: ERROR -M2 vpc run
technical
|
| Apr 15, 2024 |
Re: LSODA error code -5
technical
|
| May 11, 2024 |
Re: %RSE for IIV when expressed as %CV instead of variance
technical
|
| Jul 11, 2024 |
Re: An error when running a plasma/urine model in SS. Would you please help?
technical
|
| Jul 15, 2024 |
Re: An error when running a plasma/urine model in SS. Would you please help?
technical
|
| Jul 27, 2024 |
Re: Obtaining RSE%
technical
|
| Aug 16, 2024 |
Re: Difference between FOCEI and SAEM
technical
|
| Sep 18, 2024 |
Re: Re: 0PRED EXIT CODE = 1
technical
|
| Dec 05, 2024 |
Re: NONMEM error
technical
|
| Jan 11, 2025 |
Re: MU referencing and time-varying covariates
technical
|
| Jan 11, 2025 |
Re: [EXTERNAL] Re: MU referencing and time-varying covariates
technical
|
| Feb 23, 2025 |
Re: All PRED=0 after removing IIV
technical
|
| Dec 08, 2025 |
Re: Multiple race coding
technical
|
| Feb 23, 2026 |
Re: Logit transformation and covariate model
technical
|
| Mar 16, 2026 |
Re: $PRIOR and $MIX for ABCB1 3435 and 2677 data
technical
|