Re: Nonmem model

From: Leonid Gibiansky Date: December 17, 2003 technical Source: cognigencorp.com
From: Leonid Gibiansky - lgibiansky@emmes.com Subject: Re: [NMusers] Nonmem model Date: 12/17/2003 12:33 PM Batul I think you need initial conditions. As written, A2=A3=A4=0 at time = 0, is this correct ? Are there any source terms (doses to compartments 2, 3, or 4)? In not, then zero is the unique solution of the system for A2, A3, A4. Discrepancy between zero and your observations goes into the error term. What is the intended meaning of: CMT, which is ... 2 for the first (and only first) PD observation? I think it will be ignored since you explicitly stated that VBAC=A(2)+A(4) IPRD=VBAC Leonid

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Dec 17, 2003 Batul Parta Nonmem model
Dec 17, 2003 Leonid Gibiansky Re: Nonmem model
Dec 17, 2003 Lewis B. Sheiner Re: Nonmem model
Dec 19, 2003 Batul Parta Re: Nonmem model
Dec 19, 2003 Leonid Gibiansky Re: Nonmem model
Dec 20, 2003 Pascal Girard Re: Nonmem model
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