Re: Different population estimates

From: Leonid Gibiansky lgibiansky@emmes.com Subject: Re: [NMusers] Different population estimates Date: 11/17/2003 2:43 PM My only remaining idea is that PD time points are not the same for the subjects in the same cohort; this forces NONMEM to evaluate PRED in different (between subjects) time points, and leads to changes in integration steps along the way. To check this you may add EVID=2 time points to make sure that the sets of time points for all subjects in the same cohort are identical. Simultaneous fit may change PK profile, but should not lead to differences between population predictions for subjects with the same dose, duration, etc. Leonid