NONMEM memory vs. run time

Dear All, I noticed that the Nonmem installed with NMQUAL "big nm6" defaults instead of the standard ones results in approximately 10-times increase in the memory required to run Nonmem (on my recent problem, from 12 MB to 140 MB). I am wondering whether anybody checked how this influences the run time. Is it better (in terms of the run time) to use standard sizes, or "big" is OK if you have enough RAM? Thanks! Leonid -------------------------------------- Leonid Gibiansky, Ph.D. President, QuantPharm LLC web: www.quantpharm.com e-mail: LGibiansky at quantpharm.com tel: (301) 767 5566