Re: Output EPS(1) after an $EST step?
The only way that I know is to use
SD=SQRT(IPRED**2*THETA(10)**2+THETA(11)**2)
Y=IPRED+SD*EPS(1)
RES=DV-IPRED
IWRES = RES/SD ; same as EPS(1)
$SIGMA
1 FIX
Leonid
--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566
Quoted reply history
On 2/3/2012 3:21 PM, Dodds, Mike wrote:
> All,
>
> Is there a way to recover epsilons after an $EST step? The difference
> between DV and IPRED is epsilon for a simple additive error model.
> However, with a mixed proportional and additive error model, I can’t see
> a way to separate the two epsilon contributions to DV-IPRED.
>
> $TABLE EPS(1) after an $EST step provides a column of zeros, and the
> NONMEM manual indicates this is the expected behavior.
>
> Warm Regards,
>
> Mike Dodds