ETABAR p-value

From: Leonid Gibiansky Date: February 20, 2007 technical Source: mail-archive.com
Dear All, Could anyone help me to interpret ETAbar p value? I have: TOT. NO. OF OBS RECS: 1486 TOT. NO. OF INDIVIDUALS: 213 ETABAR: -0.52E-02 -0.27E-01 -0.93E-01 P VAL.: 0.90E+00 0.24E+00 0.81E-04 ETA1 ETA2 ETA3 ETA1 4.08E-01 ETA2 2.26E-01 2.31E-01 ETA3 0.00E+00 0.00E+00 9.70E-01 which looks too low for me for eta3. I checked that p of abs(mean(eta)) > 0.093 is about 0.17 for normally distributed variable with SD=sqrt(0.97) and about 200 patients. > sum1 <- 0 > for(i in 1:1000000) if(abs(mean(rnorm(213,0,sqrt(0.97))))> 0.093) sum1 <- > sum1+1 > print(sum1/1000000) [1] 0.168624 How exactly this p-value is computed (NONMEM V) ? Thanks Leonid
Feb 20, 2007 Leonid Gibiansky ETABAR p-value
Feb 20, 2007 Mats Karlsson RE: ETABAR p-value
Feb 21, 2007 Lars Erichsen RE: ETABAR p-value
Feb 21, 2007 Mats Karlsson RE: ETABAR p-value
Feb 21, 2007 Serge Guzy RE: ETABAR p-value
Feb 22, 2007 Majid . Vakily RE: ETABAR p-value
Feb 23, 2007 Martin Bergstrand RE: ETABAR p-value