Re: simulation problem or bug

On 5/24/2011 9:14 AM, Fidler,Matt,FORT WORTH,R&D wrote: > Leonid, > > I am unsure why this occurs. I would try the following though: > > - Change the seed number > - Rerun another control stream linked to the MSF output by the model and > change the SIGDIG to match the number of significant digits obtained from your > model and run MAXEVAL=0 to create a MSF to run the simulation from. (If you > run your simulation in this manner) > - Specify the parameters explicitly, and then run the simulation. > - Run the simulation in another version of NONMEM > > Otherwise I'm out of ideas. > > Matt. > > -----Original Message----- > From: [email protected] [mailto:[email protected]] On > Behalf Of Leonid Gibiansky > Sent: Monday, May 23, 2011 3:27 PM > To: nmusers > Subject: [NMusers] simulation problem or bug > > Dear All, > I am trying to run simulations starting from the msf file (nm 7.1). > I've done it multiple times for the current project without any > problems. BUT for one specific problem, I see a very strange behavior: > The simulation script runs just fine with SUBPROBLEMS=0 option, but > fails with any other value (including 1) with the following error: > > 0MULTIPLE SUB_PROBLEMS IS INCOMPATIBLE WITH OTHER INFORMATION > IN THE CONTROL STREAM AND INPUT MSF > > I am not sure whether it is important but the original run completed > with 134 (rounding error) estimation error and successful covariance > step (with UNCONDITIONAL option) > > Any ideas of what is the problem? > > Thanks! > Leonid > > -- > -------------------------------------- > Leonid Gibiansky, Ph.D. > President, QuantPharm LLC > web: www.quantpharm.com > e-mail: LGibiansky at quantpharm.com > tel: (301) 767 5566 > > This e-mail (including any attachments) is confidential and may be legally > privileged. If you are not an intended recipient or an authorized > representative of an intended recipient, you are prohibited from using, copying > or distributing the information in this e-mail or its attachments. If you have > received this e-mail in error, please notify the sender immediately by return > e-mail and delete all copies of this message and any attachments. > > Thank you.