Re: Error in table step

On 9/27/2015 9:29 AM, Mark Sale wrote: > Dear colleagues: > > I have a very large model (lots of ODEs, lots of data, long duration), > running parallel across several machines, using SAEM. Runs reasonably > well. But, fails the $TABLE with this error: > > 0PROGRAM TERMINATED BY FNLETA > 0PRED EXIT CODE = 1 > 0INDIVIDUAL NO. 3 ID= 5.10000000000000E+01 (WITHIN-INDIVIDUAL) > DATA REC NO. 1 > THETA= > 0.00E+00 1.19E+00 2.59E-01 5.68E+00 2.64E-01 5.69E+00 > 2.35E+00 4.17E-01 4.20E-04 6.50E-01 > 3.98E-01 1.86E-01 -3.50E-01 -2.09E-01 -1.87E+00 2.09E-01 > 1.85E-01 -1.90E-01 1.30E+00 4.82E-01 > 0.00E+00 9.54E-01 1.34E+03 1.19E+00 3.44E-01 1.78E+03 > OCCURS DURING SEARCH FOR ETA AT INITIAL VALUE, ETA=0 > F OR DERIVATIVE RETURNED BY PRED IS INFINITE (INF) OR NOT A NUMBER (NAN). > 0PROGRAM TERMINATED BY FNLETA > MESSAGE ISSUED FROM TABLE STEP > > All the THETA values of 0.00 are fixed to that value. All the other > values are very reasonable. > > So, I don't get any tables, can't to a VPC etc. I've tried running > FOCE, no better. Tried error checking that F is always positive, tried > EXIT if F is very small, I have the NOABORT option set (but I don't > think that is relevant in the $TABLE step). > > I assume it is crashing calculating the conditional ETAs (don't know why > it does OK in estimation). PRDERR only has the small number of error > from the estimation > > Anyone seen this error, any suggestions on how to get rid of it (other > than removeing subject 51)? > > Mark > > Mark Sale M.D. > > Vice President, Modeling and Simulation > > Nuventra, Inc. ™ > > 2525 Meridian Parkway, Suite 280 > > Research Triangle Park, NC 27713 > > Office (919)-973-0383 > > [email protected] <[email protected]> > > www.nuventra.com http://www.nuventra.com > > */ > /* > > */Empower your Pipeline/* > > CONFIDENTIALITY NOTICE The information in this transmittal (including > attachments, if any) may be privileged and confidential and is intended > only for the recipient(s) listed above. Any review, use, disclosure, > distribution or copying of this transmittal, in any form, is prohibited > except by or on behalf of the intended recipient(s). If you have > received this transmittal in error, please notify me immediately by > reply email and destroy all copies of the transmittal. > > ------------------------------------------------------------------------ > *From:* [email protected] <[email protected]> on > behalf of nonmem <[email protected]> > *Sent:* Wednesday, September 23, 2015 6:47 PM > *To:* Spilker, Mary; [email protected] > *Subject:* RE: [NMusers] PK-PD Modeling position available (Pfizer > Location: La Jolla, CA) > Dear Mary, l may be over qualified for the position. My current > position is equal to associate director level at Regeneron and my > experience exceeds 2 years significantly. Thank you, Pavel > > Sent via the Samsung Galaxy S® 5 ACTIVE™, an AT&T 4G LTE smartphone > > -------- Original message -------- > From: "Spilker, Mary" <[email protected]> > Date: 09/23/2015 12:49 PM (GMT-05:00) > To: [email protected] > Subject: [NMusers] PK-PD Modeling position available (Pfizer Location: > La Jolla, CA) > > All over the world, Pfizer colleagues are working together to positively > impact health for everyone, everywhere. Each position at Pfizer touches > and contributes to the success of our business and our world. That’s > why, as one of the global leaders in the biopharmaceutical industry, > Pfizer is committed to seeking out inspired new talent who share our > core values and mission of making the world a healthier place. > > *Job Summary* > > A PK-PD Principal Scientist position is available in the Translational > Modeling and Simulation group within Pharmacokinetics, Dynamics and > Metabolism (PDM) New Biologic Entities (NBE). The successful applicant > will apply state-of-the-art modeling and simulation methods to > preclinical studies that enable key drug discovery decisions from early > discovery stages to the first-in-human study. As a member of > multidisciplinary project teams, the candidate will develop and > implement quantitative mechanism-based PK-PD models which impact the > quality of decisions regarding target prioritization, therapeutic > modality selection, biomarker characterization, chemical, biotherapeutic > optimization and early clinical trial design. The individual will have > an opportunity to support a wide range of projects, largely, but not > exclusively, in the Oncology therapeutic area, covering small molecules > and biotherapeutic modalities. > > *Education & Training * > > This individual should hold a Ph.D. or equivalent degree in systems > biology, pharmacometrics, pharmaceutical sciences, (bio)engineering, > mathematics or similar disciplines where modeling and simulation is > emphasized, and 2+ years of industrial experience in practical > applications of modeling and simulation, including direct discovery > project support. > > *Equal Employment Opportunity* > > Pfizer is committed to equal opportunity in the terms and conditions of > employment for all employees and job applicants without regard to race, > color, religion, sex, sexual orientation, age, gender identity or gender > expression, national origin, disability or veteran status. Pfizer also > complies with all applicable national, state and local laws governing > nondiscrimination in employment as well as work authorization and > employment eligibility verification requirements of the Immigration and > Nationality Act and IRCA. Pfizer is an E-Verify employer. > > *How to Apply* > > To learn more about this exciting opportunity, please visit > http://www.pfizercareers.com. Search for job ID 1019326 and submit your > application online.