Re: simulation problem or bug
Bob,
The original problem was observed in nm 7.1.2. I reproduced the error in the 7.2, but the error message now hints what is the problem:
0THE SIMULATION TASK REQUIRES THAT A BETTER FINAL ESTIMATE
BE AVAILABLE IN THE MODEL SPECIFICATION FILE
OR
MULTIPLE SUB_PROBLEMS IS INCOMPATIBLE WITH OTHER INFORMATION
IN THE CONTROL STREAM AND INPUT MSF
The original problem ended with the rounding error 134; it looks like the simulation step does not like it. Is this the indended behaviour?
Thanks
Leonid
--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566
Quoted reply history
On 5/24/2011 10:58 PM, Bauer, Robert wrote:
> Leonid:
> Could you please try this problem also with NONMEM 7.1.2 and nonmem
> 7.2.0
>
> Robert J. Bauer, Ph.D.
> Vice President, Pharmacometrics
> ICON Development Solutions
> Tel: (215) 616-6428
> Mob: (925) 286-0769
> Email: [email protected]
> Web: www.icondevsolutions.com
>
> -----Original Message-----
> From: [email protected] [mailto:[email protected]]
> On Behalf Of Leonid Gibiansky
> Sent: Tuesday, May 24, 2011 9:35 AM
> To: Fidler,Matt,FORT WORTH,R&D
> Cc: nmusers
> Subject: Re: [NMusers] simulation problem or bug
>
> Matt,
> I was able to specify parameters explicitly and run simulations. So my
>
> immediate problem is solved. I am still unsure what is the problem with
> the MSF run.
> Thanks
> Leonid
>
> --------------------------------------
> Leonid Gibiansky, Ph.D.
> President, QuantPharm LLC
> web: www.quantpharm.com
> e-mail: LGibiansky at quantpharm.com
> tel: (301) 767 5566
>
> On 5/24/2011 9:14 AM, Fidler,Matt,FORT WORTH,R&D wrote:
>
> > Leonid,
> >
> > I am unsure why this occurs. I would try the following though:
> >
> > - Change the seed number
> > - Rerun another control stream linked to the MSF output by the model
>
> and change the SIGDIG to match the number of significant digits obtained
> from your model and run MAXEVAL=0 to create a MSF to run the simulation
> from. (If you run your simulation in this manner)
>
> > - Specify the parameters explicitly, and then run the simulation.
> > - Run the simulation in another version of NONMEM
> >
> > Otherwise I'm out of ideas.
> >
> > Matt.
> >
> > -----Original Message-----
> > From: [email protected]
>
> [mailto:[email protected]] On Behalf Of Leonid Gibiansky
>
> > Sent: Monday, May 23, 2011 3:27 PM
> > To: nmusers
> > Subject: [NMusers] simulation problem or bug
> >
> > Dear All,
> > I am trying to run simulations starting from the msf file (nm 7.1).
> > I've done it multiple times for the current project without any
> > problems. BUT for one specific problem, I see a very strange behavior:
> > The simulation script runs just fine with SUBPROBLEMS=0 option, but
> > fails with any other value (including 1) with the following error:
> >
> > 0MULTIPLE SUB_PROBLEMS IS INCOMPATIBLE WITH OTHER INFORMATION
> > IN THE CONTROL STREAM AND INPUT MSF
> >
> > I am not sure whether it is important but the original run completed
> > with 134 (rounding error) estimation error and successful covariance
> > step (with UNCONDITIONAL option)
> >
> > Any ideas of what is the problem?
> >
> > Thanks!
> > Leonid
> >
> > --
> > --------------------------------------
> > Leonid Gibiansky, Ph.D.
> > President, QuantPharm LLC
> > web: www.quantpharm.com
> > e-mail: LGibiansky at quantpharm.com
> > tel: (301) 767 5566