RE: covariates

From:"Leonid Gibiansky" leonidg@metrumrg.com Subject: RE: [NMusers] covariates Date: Fri, September 17, 2004 10:50 pm Nick, I think the range of disagreement even more narrow: the only point that I'd like to add to your allometric-scale CL and V representations is that we need to check whether random effects of the resulting model are independent of WT. If they are, this is great, it would be another confirmation of the general law. If, for some particular drug, random effects depend on WT even after the allometric scaling, it needs to be corrected either by changing the power x of the dependencies (CL~ WT^x,V~WT^x) or by addition of some other covariates that correlate with WT and can remove observed dependence of random effects on WT. Thanks for the references, Leonid