Re: iNTRAVENOUS VS. INTRA-ARTERIAL SAMPLING

Hi Michael, Arterial versus venous sampling could be important for anesthesia or similar problems where the time scale of interest goes down to half-a-minute or so. I did some modeling (venous and arterial sampling fro the same saubjects) that indicated that the venous concentration was delayed by 1-2 minutes relative to the arterial ones. Also, for IV bolus, Cmax arterial was higher than Cmax venous (Tmax venous was later than Tmax arterial). The difference was important during the first few minutes after the IV bolus when the rate of concentration changes was high; then, the difference gradually declined. Apart from the times when the rate of concentration changes was very high (concentration changed significantly within 1-2 minutes) the difference between arterial and venous concentrations was negligible. Leonid -------------------------------------- Leonid Gibiansky, Ph.D. President, QuantPharm LLC web: www.quantpharm.com e-mail: LGibiansky at quantpharm.com tel: (301) 767 5566 [EMAIL PROTECTED] wrote: > Hi everyone; > > Does anyone have experience modeling data where some samples were drawn intravenously, while others (sometimes even within a given patient) were drawn from an arterial line? There are no samples drawn simultaneously from both lines, unfortunately.