Re: target-mediated model - steady state - unstable system?

From: Leonid Gibiansky leonidg@metrumrg.com Subject: Re: [NMusers] target-mediated model - steady state - unstable system? Date: Thu, 27 Oct 2005 23:40:25 -0400 Pavel, I think you made a mistake somewhere. Determinant can be presented as x(Tin-Vin)2 + y, where x and y are some positive combination of the parameters (assuming that all Ks and Ts are positive). Also, it is unlikely that A4 grows unbounded. Indeed, let KETV=0 (no A4 elimination). Then on steady state KON*A(2)*A(3) = KOFF*A(4), KET *A(2) = Tin; KEV *A(3) = Vin. System with extra elimination (KETV > 0) should have lower A4 level. Leonid _______________________________________________________