Re: High spec PC setup for NONMEM - recommendations?

On 1/26/2011 10:40 AM, Mark Sale - Next Level Solutions wrote: > Ann, > We benchmarked 32 bit vs 64 bit Intel fortran with NONMEM a few years > ago, with 64 bit XP - the 64 bit version was 10-20% faster. > NONMEM does not multithread (although the next version will multi > process). IMHO, you get the most for your money with an quad core Intel > i5, it is essentially as fast as the I7, but without multithreading. In > our benchmarks, NONMEM performance correlated well with SPECfp benchmark > (www.spec.org http://www.spec.org). > I'd suggest staying away from AMD CPUs, the latest ones are advertised > as 12 core, and they are, they have 12 integer computational units, but > have only 6 floating point units, and they perform less well than i5s. > BTW, if you can wait, the Intel 8 core CPUs are supposed to be out 3rd > quarter. > > Mark > > Mark Sale MD > President, Next Level Solutions, LLC > www.NextLevelSolns.com http://www.NextLevelSolns.com > 919-846-9185 > A carbon-neutral company > See our real time solar energy production at: > http://enlighten.enphaseenergy.com/public/systems/aSDz2458 > > -------- Original Message -------- > Subject: [NMusers] High spec PC setup for NONMEM - recommendations? > From: Ann Rigby-Jones <[email protected] > <mailto:[email protected]>> > Date: Wed, January 26, 2011 9:42 am > To: "[email protected] <mailto:[email protected]>" > <[email protected] <mailto:[email protected]>> > > Dear NMUsers > We are investigating the purchase of a hyperthreaded dual quad-core > machine (8 physical cores; hyperthreaded to create 16 logical cores) > with a view to reducing the time taken for those aspects of model > validation that require multiple iterations e.g. bootstrapping, > likelihood profiling. Our current system uses NONMEM 7, with Intel > Fortran running under Windows XP Professional, 32 bit machine . A > licensed version of PLT Tools is used for graphical output and to > facilitate model development and validation. > We are wondering whether a 64bit operating system would be preferred > for optimal performance e.g. 64bit Windows 7? Any comments or > recommendations gratefully received. > With thanks and best wishes > Ann > _______________________________________________________________________ > *Ann Rigby-Jones PhD MRSC* > Research Fellow in Pharmacokinetics & Pharmacodynamics > Peninsula College of Medicine & Dentistry > N31, ITTC Phase 1 > Tamar Science Park > 1 Davy Road > Derriford > Plymouth > PL6 8BX > > _______________________________________________________________________