Re: non-linear PK

From: Leonid Gibiansky Date: October 06, 2005 technical Source: cognigencorp.com
From: Leonid Gibiansky Subject: Re: [NMusers] non-linear PK Date: Thu, 06 Oct 2005 12:27:16 -0400 Hi Jing, 1. You have way too many eta effects. Start with CL, central volume only, fix the rest to zero, at least to define the range of parameter values. You may add more later if needed. 2. This is an error: W = SQRT(THETA(8)**2+THETA(9)**2*F*F) you should use W = SQRT(THETA(8)**2+THETA(9)**2/F/F) 3. This is an error as well: DADT(1) = - K12*A(1) - A(1)*VM/(KM+C1) DADT(2) = K12*A(1) - K21*A(2) + K32*A(3) - K23*A(2) you are missing K21*A(2) in DADT(1) = - K12*A(1) - A(1)*VM/(KM+C1)+ K21*A(2) Leonid

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Oct 06, 2005 Jing Li non-linear PK
Oct 06, 2005 Leonid Gibiansky Re: non-linear PK
Oct 06, 2005 Brenda Cirincione Re: non-linear PK
Oct 06, 2005 Juan Jose Perez Ruixo Re: non-linear PK
Oct 06, 2005 Kenneth Kowalski Re: non-linear PK
Oct 06, 2005 Leonid Gibiansky Re: non-linear PK
Oct 06, 2005 Paul Hutson Re: non-linear PK
Oct 06, 2005 Toufigh Gordi Non-linear CL
Oct 06, 2005 Jing Li Re: Non-linear CL
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