Re: Capturing AUC between observation time intervals
From: Leonid Gibiansky
Subject: Re: [NMusers] Capturing AUC between observation time intervals
Date: Wed, 03 Apr 2002 16:42:40 -0500
I think you have a choice:
1. Create a data set with a lot of intermediate time points, and then come
up with the cumulative AUC=concentration*time
2. Compute AUC analytically based on the dose history and PK parameters
(the quickest way if the dose history is not too complicated)
3. Use differential equations with one of the variable being AUC (via
equation dAUC/dt=C)
4. Try to imitate (3) via additional compartment with fixed rate constants:
dA4/dt=kC4*A1-k4C*A4, k4C is about 0, kC4 is also very small but
significantly higher than k4C. Then (A4/kC4)/VC is an approximation of AUC,
if I am not mistaken (C is the central compartment).
Leonid