Re: Assessment of elimination half life of mAb
There is no such thing as half-life of elimination for the nonlinear drug. But one can compute something like half-life:
1. Half-life of the linear part (defined by CL, V1, V2, Q): this defines the half-life at high doses/high concentrations when nonlinear elimination is saturated.
2. Washout time: for the linear drug, 5 half-lives can be used to define washout time. During this time, concentrations drop approximately 2^5=32 times. So one can simulate the desired dosing (single dose or steady state), find the time from Cmax to Cmax/32 and call it washout time (or time to Cmax/64 to be conservative)
Thanks
Leonid
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On 4/28/2021 5:17 PM, Niurys.CS wrote:
> Dear all
>
> I need some help to assess the elimination half life of a monoclonal antibody. The model that describes the data is a QSS aproximation of TMDD with Rmax constant. The model includes two binding process of mAb to its target: in central and peripheral compartments. Is there any specific equation to calcule lambda z and the elimination half life for each of the TMDD aproximations?
>
> Thanks
> Niurys