Re: PRED in a Hill binding model

From: Leonid Gibiansky <lgibiansky@emmes.com> Subject: Re: [NMusers] PRED in a Hill binding model Date: 6/18/2003 5:29 PM You mentioned that you use INDIVIDUAL PK parameters, so although your PD parameters are the same for the entire population, the model uses individual concentrations. Therefore, effect that depend on concentration differ from subject to subject. To get population estimates, you either need to fit a joint PK/PD model, or introduce fictitious "average" patient with population PK parameters, or add PD part (with fixed parameters) into your PK model and compute it there. Leonid _______________________________________________________