Re: Resetting af single compartment
From the NM help for CMT data item:
Other-Type Event:
A positive value of CMT specifies a compartment to be turned on.
A negative value of CMT specifies a compartment to be turned off.
So my guess is that
EVID CMT
2 -3
2 3
Should reset this particular compartment 3 (although I never tried it)
Leonid
--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566
Elassaiss - Schaap, J. (Jeroen) wrote:
> Thomas, Two solutions (their smart scale is up to you to judge ;-): 1 - rewrite the model so you don't need the changepoint (best approach IMHO) 2 - I guess you could switch the model to a different differential equation instead
>
> e.g.
> CHNG = KIN*(1-EFF) - (A(3)*SLCT+A(4)*(1-SLCT))*KOUT
> DADT(3) = SLCT*CHNG
> DADT(4) = (1-SLCT)*CHNG
> But I have not tested that approach. I guess it should work.
>
> Best regards,
>
> Jeroen
>
> *Jeroen Elassaiss-Schaap, PhD*
> Modeling & Simulation Expert
> Pharmacokinetics, Pharmacodynamics & Pharmacometrics (P3)
> Early Clinical Research and Experimental Medicine
> Schering-Plough Research Institute
> T: +31 41266 9320
>
> ------------------------------------------------------------------------
>
> *From:* [email protected] [ mailto: [email protected] ] *On Behalf Of *TKT (Thomas Klitgaard)
>
> *Sent:* Thursday, 23 April, 2009 15:20
> *To:* [email protected]
> *Subject:* [NMusers] Resetting af single compartment
>
> Dear all
>
> I need to reset a single compartment in a model of several cmts, without resetting the whole system for the
>
> subject (which EVID=4 would do). Is there a *smart* way to do this?
>
> Thanks,
>
> Thomas
>
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