Re: Modeling targeted mediated drug disposition using Quasi-equilibrium model
Xiaofeng
you can use:
Rfree= Rtot *KD/(KD+Cfree)
Leonid
--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566
Quoted reply history
On 7/6/2012 11:40 AM, Wang, Xiaofeng wrote:
> Dear users,
>
> I am working on monoclonal antibody exhibiting target mediated drug
> dispositionand trying to fit a quasi-equilibriummodel described by
> Magerand Krzyzanski[PharmRes 22(10):1598]. In the paper, the
> quasi-equilibriumwas fitted to total drug conc. and total target conc.
> We observed total drug conc., total target conc., and free target conc.
> I am trying to fit the model to not only total drug conc. and total
> target conc. but also free target conc. simutaneously. But I did not
> figure out how I can incorporate free target conc. in the model using
> KDinstead of Konand Koff. Could anybody please give me some suggestion
> or help? Thank you.
>
> Best,
>
> Xiaofeng
>
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