Re: computation of exponential error model for RUV
yes, it does at estimation, not sure about simulations step.
If you need true exponential error, log-transform of DV and model predictions is needed
Leonid
Quoted reply history
On 7/19/2021 11:34 AM, Guidi Monia wrote:
> Dear colleagues,
>
> We would like to compare the NONMEM predictions with those obtained by a Bayesian TDM software for models describing the residual unexplained variability with exponential errors.
>
> We need to know if NONMEM performs a first order Taylor expansion of the exponential error when data are fitted by the FOCE method:
>
> Y=F*EXP(EPS(1)) -> Y= F*(1+EPS(1)).
>
> Could someone help with this?
>
> Thanks in advance
>
> Monia
>
> Monia Guidi, PhD
>
> Pharmacometrician
>
> Service of Clinical Pharmacology | University Hospital and University of Lausanne
>
> Center of research and innovation in Clinical Pharmaceutical Sciences | University Hospital and University of Lausanne
>
> BU17 01/193
>
> CH-1011 Lausanne
>
> email: [email protected] <mailto:[email protected]>
>
> tel: +41 21 314 38 97
>
> *CHUV**
> **_centre hospitalier universitaire vaudois_*
>
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