Re: Assessment of elimination half life of mAb
I am not aware of any papers specifically addressing the half-live issue, but there are tons of original papers and tutorials on TMDD, just search the web
Thanks
Leonid
Quoted reply history
On 4/29/2021 9:48 AM, Niurys.CS wrote:
> Dear Leonid,
>
> Many thanks for clearing up my doubt. Can you suggest me any paper to go into this topic in any depth.
>
> Best,
> Niurys
>
> El 28/04/2021 19:34, "Leonid Gibiansky" < [email protected] < mailto: [email protected] >> escribió:
>
> There is no such thing as half-life of elimination for the nonlinear
> drug. But one can compute something like half-life:
>
> 1. Half-life of the linear part (defined by CL, V1, V2, Q): this
> defines the half-life at high doses/high concentrations when
> nonlinear elimination is saturated.
>
> 2. Washout time: for the linear drug, 5 half-lives can be used to
> define washout time. During this time, concentrations drop
> approximately 2^5=32 times. So one can simulate the desired dosing
> (single dose or steady state), find the time from Cmax to Cmax/32
> and call it washout time (or time to Cmax/64 to be conservative)
>
> Thanks
> Leonid
>
> On 4/28/2021 5:17 PM, Niurys.CS wrote:
>
> Dear all
> I need some help to assess the elimination half life of a
> monoclonal antibody.
> The model that describes the data is a QSS aproximation of TMDD
> with Rmax constant. The model includes two binding process of
> mAb to its target: in central and peripheral compartments.
> Is there any specific equation to calcule lambda z and the
> elimination half life for each of the TMDD aproximations?
> Thanks
> Niurys