RE: protein binding

From: Leonid Gibiansky lgibiansky@emmes.com Subject: RE:[NMusers] protein binding Date: Thu, June 24, 2004 10:34 am Anthe I have not been on the course, so I do not know details of the model but this equation raises questions: >DADT(1)=-K10*A(2)-K10*A(2)*BMAX*KD/(KD+A(2))**2 If A1 is the total amount (free + bound), A2 is the free drug, then - K10*A2 describes elimination of the drug where elimination is the first order process proportional to the free concentration. What is the meaning of the second part ? A(2)*BMAX*KD/(KD+A(2))**2 = A(2)*BMAX/(KD+A(2)) * KD/(KD+A(2))= A3*KD/KD+A2) Should we use simply DADT(1)=-K10*A(2) ? Leonid