Re: Specify full OMEGA matrix for simulation
Looks like a bug.
Workaround is to use a very small diagonal value (1E-30)
Leonid
Quoted reply history
On 7/6/2023 6:01 AM, Philip Harder Delff wrote:
> Hi all,
>
> I am trying to specify a full OMEGA matrix for simulation purpose. I get issues because some diagonals are zero and some are positive. If I write
>
> $OMEGA BLOCK(3) FIX
> 0.078
> 0 0.02
> 0 0 0
>
> I get this error:
> AN ERROR WAS FOUND ON LINE 34 AT THE APPROXIMATE POSITION NOTED:
> 0 0 0
>
> 224 A VARIANCE IS ZERO, BUT THE BLOCK IS NOT FIXED TO ZERO.
>
> I know I could do:
> $OMEGA BLOCK(2) FIX
> 0.078
> 0 0.02
> $OMEGA FIX
> 0
>
> However, that would be complicated to generate programmatically. Anyway I can tell Nonmem to use a specified OMEGA matrix as is for a simulation?
>
> Thank you,
> Philip