Re: Incorporating duplicate assays

From: Leonid Gibiansky leonidg@metrumrg.com Subject: Re: [NMusers] Incorporating duplicate assays Date: Wed, 16 Nov 2005 15:25:21 -0500 Hi Paul, Technically, this is correct. I had duplicate measurements in some of the NONMEM runs, and there were no complaints from the program concerning the duplicate times. For the actual data set, residual error consists of the assay error + unexplained error. I think that the second component is usually larger. Repeated measurements at the same point cannot help with that part. If you have the same number of measurement for the majority of points, you can average before running the model (thus creating the new more precise and less variable assay as an average of x number of measurements at each point). Thanks Leonid