Mats Karlsson

207 messages, 1996–2026

Date Subject
Aug 01, 1996 Re: Design Evaluation for PK Substudies in Phase III technical
Oct 17, 1996 Re: Weights for AUC in a logistics regression technical
Jul 23, 1997 Re: OMEGA and SIGMA in INFN technical
Sep 26, 1997 Uncertainty in CV's technical
Dec 17, 1997 Re: NONMEM and identification of drug-drug interactions technical
Dec 19, 1997 RE: NONMEM and identification of drug-drug interactions technical
Dec 19, 1997 Re: Drug Interactions technical
Sep 25, 1998 Re: Box-Cox transformation in NONMEM technical
Oct 07, 1998 Re: stepwise zero order process technical
Jan 07, 1999 Re: Dble exponential error model technical
Feb 01, 1999 PREDvsDV technical
Feb 04, 1999 Re: Validation technical
May 26, 1999 Re: Question: Number of ETA and EPS in statistic significance technical
Jun 11, 1999 Re: Nagaraja technical
Nov 13, 1999 Re: Standard error of 'secondary' parameters technical
Nov 23, 1999 Re: IOV effects technical
Nov 23, 1999 Re: IOV effects technical
Dec 10, 1999 Re: metabolite modeling technical
Mar 12, 2000 Re: ADVAN4!!! technical
Apr 05, 2000 Re: INITIAL OBJ FUNCTION ERROR technical
Jun 23, 2000 Re: weighted residuals technical
Aug 07, 2000 Re: [Fwd: CLIN PHAR STAT: Mixed Vs Fixed] technical
Aug 12, 2000 Re: Number of evaluations of differential equations technical
Sep 11, 2000 Re: missing data items technical
Oct 05, 2000 Re: Bayesian estimation: a specific case technical
Nov 14, 2000 Re: 95% CI of paramter estimate technical
Nov 14, 2000 Re: 95% CI of parameter estimate technical
Nov 21, 2000 Re: Stepwise regression technical
Nov 27, 2000 Rate constants technical
Dec 11, 2000 Re: Stepwise regression technical
Dec 13, 2000 Re: Help please... technical
Feb 26, 2001 Re: SIGMA estimates technical
Mar 27, 2001 Re: NONPAR technical
Mar 30, 2001 Re: Bootstrap resampling! technical
May 10, 2001 Re: Parameterization!!! technical
May 13, 2001 Re: Parameterization!!! technical
May 24, 2001 Re: Error models and weighting technical
May 31, 2001 Re: Covariate screening technical
Aug 22, 2001 Re: NNMUSERS : Non-positive semi-definite message technical
Feb 27, 2002 Re: "Tip of the Week #3 - February 25, 2002" - Coding technical
Apr 04, 2002 Re: Capturing AUC between observation time intervals technical
Apr 29, 2002 Re: When to do transformation of data? technical
Apr 29, 2002 Re: When to do transformation of data? technical
May 02, 2002 Re: sequential PK/PD technical
May 02, 2002 Re: sequential PK/PD technical
May 27, 2002 Re: Several metabolites in urine technical
Oct 07, 2002 Re: OMEGA HAS A NONZERO BLOCK technical
Apr 04, 2003 Re: NONMEM Tips #16 - April 2, 2003 - Modeling a "baseline" componentand an additive "drug" component technical
May 23, 2003 Re: Poor PRED estimates technical
Feb 18, 2004 Re: Implementation of interindividual variability in residual variance technical
Jun 05, 2004 RE: $OMEGA blocks and log-likelihood profiling technical
Jun 16, 2004 RE: Renal CL estimations technical
Aug 09, 2004 RE: Changing Clearance over time : Enzyme auto-induction technical
Aug 23, 2004 RE: Outliers and the FDA guideline technical
Aug 23, 2004 RE: Decrease in OFV with a fixed effect technical
Sep 02, 2004 RE: WRES vs. time technical
Sep 22, 2004 RE: BOV technical
Sep 22, 2004 RE: BOV technical
Sep 22, 2004 RE: BOV technical
Sep 23, 2004 RE: BOV technical
Sep 23, 2004 RE: BOV technical
Sep 23, 2004 RE: BOV technical
Nov 14, 2004 RE: sample size technical
Nov 14, 2004 RE: sample size technical
Nov 15, 2004 RE: sample size technical
Nov 15, 2004 RE: sample size technical
Jan 17, 2005 RE: Number of subject and population PK/PD modeling technical
Mar 04, 2005 Re: Plcebo Corrected PK/PD technical
Mar 04, 2005 Re: Plcebo Corrected PK/PD technical
May 04, 2005 RE: Missing mixed continuous and categorical data technical
May 18, 2005 RE: Probabilistic model technical
May 19, 2005 RE: Probabilistic model technical
Sep 16, 2005 RE: Interpreting IOV technical
Nov 16, 2005 RE: Incorporating duplicate assays technical
Nov 18, 2005 RE: Incorporating duplicate assays technical
Jan 18, 2006 RE: covariate selection question technical
Jan 24, 2006 RE: covariate selection question technical
Feb 06, 2006 RE: interoccasion variability technical
Mar 28, 2006 RE: restraining eta code event
Mar 28, 2006 RE: restraining eta code event
Mar 29, 2006 RE: GAM analysis and further action technical
Sep 26, 2006 RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION technical
Sep 26, 2006 RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION technical
Sep 27, 2006 RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION technical
Sep 29, 2006 RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION technical
Sep 30, 2006 RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION technical
Oct 02, 2006 RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION technical
Oct 02, 2006 RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION technical
Feb 20, 2007 RE: ETABAR p-value technical
Feb 21, 2007 RE: ETABAR p-value technical
Mar 30, 2007 RE: Modeling Growth Hormone Pulsatility technical
May 24, 2007 RE: XPOSE4 cur.db error technical
Jul 11, 2007 RE: Interindividual variability in residual variance technical
Jul 12, 2007 RE: Interindividual variability in residual variance technical
Aug 15, 2007 RE: Model Comparison and Viewing of Output technical
Jan 07, 2008 RE: AUC Calculation in Simulation with and without EST technical
Jun 07, 2008 RE: 95% prediction interval and $OMEGA technical
Sep 02, 2008 RE: unbalanced design technical
Sep 03, 2008 RE: unbalanced design technical
Nov 14, 2008 RE: Very small P-Value for ETABAR technical
Dec 09, 2008 RE: FO vs FOCE, sequential vs simultaneous technical
Mar 03, 2009 RE: The Standard Two-Stage and ELS technical
Mar 21, 2009 RE: calculation of AUC technical
Mar 22, 2009 RE: calculation of AUC technical
Mar 25, 2009 RE: calculation of AUC technical
Apr 14, 2009 RE: VPC with Mixture Model technical
Apr 14, 2009 RE: OMEGA BLOCK with mixture model? technical
Apr 15, 2009 RE: VPC with Mixture Model technical
Apr 16, 2009 RE: OMEGA BLOCK with mixture model? technical
Apr 16, 2009 RE: OMEGA selection technical
Apr 19, 2009 RE: OMEGA BLOCK with mixture model? technical
Apr 23, 2009 RE: Resetting af single compartment technical
Jun 09, 2009 RE: Time to event analysis using NONMEM technical
Jun 17, 2009 RE: estimating Ka from dataset combining rich sample study and sparse sampling study technical
Jul 09, 2009 Post-doctoral positions available at Uppsala Univeristy job
Jul 24, 2009 RE: Modeling of two time-to-event outcomes technical
Jul 27, 2009 RE: AW: Simulations with/without residual error technical
Aug 05, 2009 RE: COND LAPLACE LIKELIHOOD technical
Aug 07, 2009 RE: Re: count simulations technical
Aug 23, 2009 RE: Linear VS LTBS technical
Aug 24, 2009 RE: Linear VS LTBS technical
Aug 24, 2009 RE: Honest measurements technical
Aug 24, 2009 RE: What does convergence/covariance show? technical
Aug 25, 2009 RE: What does convergence/covariance show? technical
Aug 26, 2009 RE: What does convergence/covariance show? technical
Sep 24, 2009 RE: time-dependent residual error models technical
Sep 28, 2009 researcher in PBPK modelling job
Nov 18, 2009 RE: Modeling biomarker data below the LOQ technical
Dec 21, 2009 RE: BSV and BOV interaction technical
Feb 08, 2010 RE: Dilemma with PPK parameters technical
May 29, 2010 RE: distribution assumption of Eta in NONMEM technical
May 30, 2010 RE: distribution assumption of Eta in NONMEM technical
May 31, 2010 RE: distribution assumption of Eta in NONMEM technical
Jun 01, 2010 RE: distribution assumption of Eta in NONMEM technical
Jun 02, 2010 FW: distribution assumption of Eta in NONMEM technical
Aug 06, 2010 RE: ALAG with transit model technical
Aug 11, 2010 RE: Baseline as a covariate technical
Nov 02, 2010 RE: Rational of using IOV technical
Nov 08, 2010 RE: Rational of using IOV technical
Mar 28, 2011 RE: Autoinduction model - An increased clearance(day 1- 14) technical
Mar 31, 2011 RE: basic questions... technical
Apr 19, 2011 PhD student positions in pharmacometrics open for application job
Jul 11, 2011 RE: Confidence intervals of PsN bootstrap output technical
Dec 22, 2011 Eight Postdoctoral research positions in Pharmacometrics at Uppsala Univeristy job
Feb 03, 2012 RE: Output EPS(1) after an $EST step? technical
Feb 22, 2012 RE: OMEGA priors using modes of inverse Wishart matrix technical
Feb 23, 2012 FW: OMEGA priors using modes of inverse Wishart matrix technical
Feb 24, 2012 RE: Coding delayed covariate effects technical
Mar 05, 2012 RE: time-dependent clearance model technical
May 26, 2012 RE: Question about handling BLOQ data with mixture model technical
Jun 23, 2012 RE: Priors and covariate model building technical
Jul 12, 2012 RE: Question about interoccation variability technical
Jul 23, 2012 RE: Question about mixture model of Ka technical
Aug 13, 2012 Covariate modeling course in Philadelphia Oct 22-23, 2012 event
Aug 28, 2012 Covariate modeling course in Philadelphia Oct 22-23, 2012 event
Sep 02, 2012 RE: single-patient AUC technical
Sep 20, 2012 RE: time-to-event simulation based diagnostic technical
Oct 09, 2012 RE: VPC question technical
Nov 08, 2012 RE: RE: Proper way to handle the pre-first dose PK observation for non-endogenous drug technical
Nov 22, 2012 RE: M3 method with log transformed data technical
Jan 26, 2013 RE: FW: Intersubject Variability in Logistic Regression technical
Feb 14, 2013 RE: Bootstrap, re-using inital model run results technical
Mar 07, 2013 RE: M3 method and multiple LOQ values technical
May 07, 2013 RE: Mixture model simulation technical
May 08, 2013 Covariate model building course before PAGE event
Aug 24, 2013 RE: Time-varing covariate technical
Aug 25, 2013 Re: Time-varing covariate technical
Aug 27, 2013 RE: Time-varing covariate technical
Aug 28, 2013 RE: Time-varing covariate technical
Sep 20, 2013 RE: Parameter Estimation in IF Conditioning Statement technical
Mar 19, 2014 RE: Prediction with parameter estimates on new data technical
Oct 02, 2014 SV: OMEGA matrix technical
Nov 19, 2014 RE: Genotype data missing in some individuals technical
Mar 17, 2015 Stockholm Uppsala Pharmacometrics meeting April 15th technical
Apr 21, 2015 RE: variation of time values in output data technical
May 27, 2015 RE: RE: Dataset coding for baseline endogenous substance technical
Jun 08, 2015 RE: Fwd: Should we generate VPCs with or without uncertainty? technical
Jun 08, 2015 RE: Fwd: Should we generate VPCs with or without uncertainty? technical
Jun 23, 2015 RE: Simulo: a new service for drug trial simulation technical
Jul 28, 2015 RE: Is it reasonable to add covarite to PD parameters kin or kout? technical
Dec 11, 2015 RE: Error in LSODA: Code -5 technical
Dec 11, 2015 DDMoRe launches a new platform technical
Dec 22, 2015 RE: Problem of STS in NONMEM technical
Jan 12, 2016 Re: Parameter Uncertainty and Covariate effects technical
May 13, 2016 RE: Splitting the residual error technical
May 14, 2016 RE: Splitting the residual error technical
Jun 02, 2016 RE: Additive plus proportional error model for log-transform data technical
Jun 02, 2016 RE: Additive plus proportional error model for log-transform data technical
Oct 21, 2016 DDMoRe Model Repository reaching 100 models technical
Nov 11, 2016 RE: $PRIOR with normal for OMEGA? technical
Nov 28, 2018 RE: Time After Dose example in help/html technical
Dec 18, 2018 RE: Time After Dose example in help/html technical
Feb 06, 2019 RE: Ordinal data model: Incorporation of variability & assessment of predictive performance technical
Feb 06, 2019 RE: Ordinal data model: Incorporation of variability & assessment of predictive performance technical
Mar 14, 2019 RE: VPCs confidence intervals? technical
May 16, 2019 RE: inclusion of covariates with $PRIOR technical
Dec 16, 2019 2 Advanced NONMEM courses given in both US and Europe in 2020 event
Dec 20, 2019 UPSS - Uppsala Pharmacometric Summer School 2020 event
Feb 06, 2020 2 Advanced NONMEM courses given in both US and Europe in 2020 event
Jun 02, 2020 Two online NONMEM courses for East Asia, Japan and Oceania, June 22-23 & June 25-26 event
Jun 02, 2020 Two online NONMEM courses for East Asia, Japan and Oceania, June 22-23 & June 25-26 event
Feb 01, 2023 Uppsala Pharmacometric Summer School - UPSS event
Mar 02, 2023 Uppsala Pharmacometric Summer School - UPSS event
Jan 25, 2024 Uppsala Pharmacometric Summer School (UPSS) 2024 event
Mar 23, 2024 FW: Uppsala Pharmacometric Summer School (UPSS) 2024 -reminder of approaching deadline event
Feb 07, 2025 Uppsala Pharmacometric Summer School (UPSS) 2025 event
Jan 28, 2026 Uppsala Pharmacometric Summer School (UPSS) 2026 event