RE: Incorporating duplicate assays

From: "Mats Karlsson" mats.karlsson@farmbio.uu.se Subject: RE: [NMusers] Incorporating duplicate assays Date: Fri, 18 Nov 2005 11:05:49 +0100 Hi Vladimir, The L2 data item is necessary as the duplicates will share a common residual error (due to error in dosing history, sampling time, model misspecification etc). The only way to have two observations share an EPS is by using the L2 data item. There is however no need to estimate off-diagonal elements of the SIGMA matrix. Best regards, Mats -- Mats Karlsson, PhD Professor of Pharmacometrics Div. of Pharmacokinetics and Drug Therapy Dept. of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 SE-751 24 Uppsala Sweden phone +46 18 471 4105 fax +46 18 471 4003 mats.karlsson@farmbio.uu.se