RE: BOV
From: "Mats Karlsson" mats.karlsson@farmbio.uu.se
Subject: RE: [NMusers] BOV
Date: Thu, September 23, 2004 10:32 am
Hi,
Sure you can allow BOV to vary with time. I'm not so sure that you'll
ever find something particularly stunning. I did see it increase once in
a study with unequally positioned occasions (similar to Ken's example -
two narrowly spaced and one distant occasion). I think it is much more
useful and important to investigate whether residual variability varies
with time (after dose). It is a different level of random effect, but
the same principle. In particular for oral data (but also for infusions)
residual variability is considerably higher during the ascending
(absorption) phase than the descending (elimination) phase.
Best regards,
Mats
--
Mats Karlsson, PhD
Professor of Pharmacometrics
Div. of Pharmacokinetics and Drug Therapy
Dept. of Pharmaceutical Biosciences
Faculty of Pharmacy
Uppsala University
Box 591
SE-751 24 Uppsala
Sweden
phone +46 18 471 4105
fax +46 18 471 4003
mats.karlsson@farmbio.uu.se