RE: BOV

From:"Mats Karlsson" mats.karlsson@farmbio.uu.se Subject: RE: [NMusers] BOV Date: Wed, September 22, 2004 3:03 pm Hi Ken, I'm not going to run your example, but why complicate things unnecessarily. It is a lot easier and conceptually just as valid to assume that you can get a precise estimate of CL at each occasion. Thus you can do you example with just two levels of random effects. (My prediction in this or the original example is that the full model will be supported without having to go to a large number of occasions). The analysis model suggested by Fabrice (Model 3 below) does not really make sense. It predicts either (i) that overall variability is lower on the first occasion than on the other, or (ii) that there is a correlation between the BSV eta and every BOV eta for multiple occasions. The latter is problematic for a number of reasons. Best regards, Mats -- Mats Karlsson, PhD Professor of Pharmacometrics Div. of Pharmacokinetics and Drug Therapy Dept. of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 SE-751 24 Uppsala Sweden phone +46 18 471 4105 fax +46 18 471 4003 mats.karlsson@farmbio.uu.se