RE: Time to event analysis using NONMEM

From: [email protected] [mailto:[email protected]] On Behalf Of [email protected] Sent: Tuesday, June 09, 2009 5:24 PM To: [email protected] Subject: [NMusers] Time to event analysis using NONMEM Dear NMUsers I am trying to analyse time to single event data using NONMEM VI. I am getting the following termination message. If some body could point out what I am doing wrong or may be elaborate on the error message that would be very helpful. Thanks in advance Anubha 0PROGRAM TERMINATED BY OBJ ERROR IN CLIK WITH INDIVIDUAL 1 ID=0.40000000E+01 CONDITIONAL LIKELIHOOD FOR DATA FROM OBS RECORD 1 ESTIMATED TO BE NEGLIGIBLE MESSAGE ISSUED FROM ESTIMATION STEP AT INITIAL OBJ. FUNCTION EVALUATION Data set C STUD ID TIME CS DOSE . 101 4 111 0 0.4 . 101 5 51 0 0.4 . 101 6 31 0 0.8 C Missing DV 101 7 . . 0.8 . 101 8 59 0 1.6 . 101 9 477 1 3.2 . 101 11 278 0 3.2 . 101 12 58 0 6.4 CS=1 is the censored event TIME is in days Model file: $PROB Time To Event data $INPUT C STUD ID TIME=DV CS DOSE $DATA IGNORE=C $SUBR ADVAN=6 TOL=6 $MODEL COMP=(RISK) $PK BASE = THETA(1)*EXP(ETA(1)) ;the ETA is a placeholder here $DES DADT(1)=BASE ;hazard $ERROR HZ = A(1) ;hazard SUR = EXP(-HZ) ;survival probability DENS=HZ*SUR Y = (1-CS)*DENS + CS*SUR $THETA (0,.025) ; BASE $OMEGA 0 FIX $ESTIM MAXEVAL=9990 METHOD = COND LAPLACE LIKE PRINT=1 MSFO=msfb01 $COV PRINT=E THIS EMAIL AND ANY ATTACHED FILES ARE CONFIDENTIAL. If you are not the intended recipient you are notified that any disclosure, reproduction,copying, distribution, or action taken in reliance on the contents of this information is strictly prohibited. If you have received this transmission in error please notify the sender immediately and then delete this email. Email transmission cannot be guaranteed to be secure or error free as information could be intercepted, corrupted, lost, destroyed,arrive late or incomplete, or contain viruses. The company/sender accepts no liability for any changes made to this email during transmission or any damage caused by any virus transmitted by this email. Any views or opinions expressed in this email are solely those of the author and do not necessarily represent those of the company. The company/sender accepts no liability for the content of this email, or for the consequences of any actions taken on the basis of the information provided, unless that information is subsequently confirmed in writing.