RE: sample size

From: "Mats Karlsson" mats.karlsson@farmbio.uu.se Subject: RE: [NMusers] sample size Date: Sun, November 14, 2004 4:13 am Hi, I disagree with Pascal. If you look upon the options: Population analysis, standard two-stage, nave pooling or throw away the result of your experiment, population analysis may well be the best option. I dont know anyone who has compared methods with as few as 4 subjects, but we looked at 8 subjects with rich sampling and found that pop analysis was better than STS for the situations we studied (AAPS PharmSci. 2000;2(3):E32). Best regards, Mats -- Mats Karlsson, PhD Professor of Pharmacometrics Div. of Pharmacokinetics and Drug Therapy Dept. of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 SE-751 24 Uppsala Sweden phone +46 18 471 4105 fax +46 18 471 4003 mats.karlsson@farmbio.uu.se