Re: Plcebo Corrected PK/PD

From: "Mats Karlsson" Mats.Karlsson@farmbio.uu.se Subject: Re: [NMusers] Plcebo Corrected PK/PD Date: Fri, March 4, 2005 11:51 pm Nick, I read your model carelessly. The point I made does not apply to this (intercept/symptomatic) model, but to one where the drug effect slows disease progression, i.e S(t) = S0 + (alpha + beta*ce(t))*t With variations in Ce being unimportant, it is probably clear that with knowing only the variance of alpha from the placebo group, many combinations of variance in beta and covariance(alpha,beta) may exlain the variability in the trt group. If you want to say that the resolution comes from variations in Ce, I won't argue, but it may not always be the case in practise. Mats