RE: Number of subject and population PK/PD modeling

From: "Mats Karlsson" mats.karlsson@farmbio.uu.se Subject: RE: [NMusers] Number of subject and population PK/PD modeling Date: Mon, January 17, 2005 4:33 am Dear Toufigh, We investigated the properties of non-linear mixed effects modeling and standard-two-stage for some subject-sparse (n=8), data-rich, situations and found that MEM was better, at least when using FOCE (AAPS PharmSci. 2000;2(3):E32). Best regards, Mats