Re: Standard error of 'secondary' parameters
Date: Sat, 13 Nov 1999 04:55:27 +0100
From: Mats Karlsson <Mats.Karlsson@biof.uu.se>
Subject: Re: Standard error of 'secondary' parameters
Mark,
We have some experience where the SE's of NONMEM were quite OK (JPB 26:207-46). We also have results indicating that the log likelihood approach may be severely biased, and therefore I wouldn't agree with the statement "the log likelihood approach is much more robust" based on theoretical considerations alone.
Best regards,
Mats