RE: BOV

From: "Mats Karlsson" Subject: RE: [NMusers] BOV Date: Wed, September 22, 2004 5:10 pm Nick, I understand that you get a biased estimate of BSV if you do it the way you do it in Excel - taking the mean of each subject's CL values to be the true value of CL. Fortunately, in mixed effects models that's not what happens (at least not should happen). My prediction is that no bias will occur in the examples run by Ken and me. The show must go on, Mats -- Mats Karlsson, PhD Professor of Pharmacometrics Div. of Pharmacokinetics and Drug Therapy Dept. of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 SE-751 24 Uppsala Sweden phone +46 18 471 4105 fax +46 18 471 4003 mats.karlsson@farmbio.uu.se