Re: Box-Cox transformation in NONMEM

From: Mats Karlsson <Mats.Karlsson@biof.uu.se> Subject: Re: Box-Cox transformation in NONMEM Date: 25 Sep 1998 10:20:16 -0400 Dear Vladimir, We applied a Box-Cox transformation when analyzing leucopenia data that were highly skewed (Clin. Pharm&Ther 1995;57:325-34). We didn't try to estimate lambda as part of the model though. Best regards, Mats ________________________________________________________ Mats Karlsson, PhD Uppsala University Div. of Biopharmaceutics and Pharmacokinetics Dept. of Pharmacy/ Box 580, SE-751 23 Uppsala, Sweden Internet: mats.karlsson@biof.uu.se Phone: +46 18 471 41 05 Fax: +46 18 471 40 03