Re: Covariate screening

From: Mats Karlsson <Mats.Karlsson@farmbio.uu.se> Subject: Re: Covariate screening Date: Thu, 31 May 2001 16:14:01 +0200 Dear Peter, I don't know if anyone has done exhaustive looks at covariate modesl using NONMEM. It would be requiring quite a lot of runs for all but the simplest cases if you want to do statistical simulations. Two papers I know of (there may well be more) that address the issue at least partially are Jonsson EN, Karlsson MO. Automated covariate model building within NONMEM. Pharm Res. 1998 Sep;15(9):1463-8. and a paper by Kowalski et al. in the next issue of J Pharmacokin Pharmacodyn Best regards, Mats -- Mats Karlsson, PhD Professor of Pharmacometrics Div. of Pharmacokinetics and Drug Therapy Dept. of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 SE-751 24 Uppsala Sweden phone +46 18 471 4105 fax +46 18 471 4003 mats.karlsson@farmbio.uu.se