Re: Bayesian estimation: a specific case

From: Mats Karlsson <Mats.Karlsson@biof.uu.se> Subject: Re: Bayesian estimation: a specific case Date: Thu, 05 Oct 2000 08:55:28 +0200 Dear Quyen, I agree with what both Joga and Pierre writes. If you do use your model from Pop1 to obtain individual Bayes estimates of Pop2, then you should use a comparison of the individual estimates of Pop2 with the population parameters of pop1 as a diagnostic. If the individual estimates of a parameter in pop2 are not unbiased compared to the typical value of the parameter in the pop1 model, that is a sign that the two populations have different pharmacokinetics (and you can definately gain more information from doing what Joga suggests in 2 below). If the individual estimates of pop2 are not biased compared to parameters of the pop1 model, that is a sign of similarity between the two populations and/or lack of information in Pop2 about the parameter in question. If such lack of bias is true for all parameters, less is to be gained by combining the data sets. Best regards, Mats -- Mats Karlsson, PhD Professor of Biopharmaceutics and Pharmacokinetics Div. of Biopharmaceutics and Pharmacokinetics Dept of Pharmacy Faculty of Pharmacy Uppsala University Box 580 SE-751 23 Uppsala Sweden phone +46 18 471 4105 fax +46 18 471 4003 mats.karlsson@biof.uu.se