Re: sequential PK/PD

From: Mats Karlsson Subject: Re: [NMusers] sequential PK/PD Date: Thu, 02 May 2002 17:43:41 +0200 Dear Raj, I assume that method 1, corresponds to method 3 in my notation and your method 2 corresponds to my method 1 (just to keep things clear :-)). If so, I would agree that OFV is not a suitable method of comparison. If I took the trouble of doing things more than one way, I would look for consistency in PD parameter estimates between methods. If I wouldn't get that, I would be worried and look into it more closely. I would assume that there is a explanation, probably rather case specific. Best regards, Mats -- Mats Karlsson, PhD Professor of Pharmacometrics Div. of Pharmacokinetics and Drug Therapy Dept. of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 SE-751 24 Uppsala Sweden phone +46 18 471 4105 fax +46 18 471 4003 mats.karlsson@farmbio.uu.se