Re: "Tip of the Week #3 - February 25, 2002" - Coding

From:Mats Karlsson [mailto:Mats.Karlsson@farmbio.uu.se] Subject:Re: [NMusers] "Tip of the Week #3 - February 25, 2002" - Coding Time After Dose(TAD) and ... the NONMEM Coding Challenge #1 Date:Wed, February 27, 2002 10:20 am Hi, Rather than trying to answer the difficult ADDL problem, I'd just like to say that Nick and Bill kindly made this oppotunity to point out (and warn) that Xpose allows an even simpler way to calculate TAD. In Xpose, TAD is calculated (use "managing databases option 24.2") from the table files assuming that any non-observation record (i.e. WRES=0) is a dosing record. Thus, the generation of TAD in Xpose won't appropriately handle ADDL records, SS infusions or EVID=2 (observations before the first dose will be assumed to be zero though). Mats Mats Karlsson, PhD Professor of Pharmacometrics Div. of Pharmacokinetics and Drug Therapy Dept. of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 SE-751 24 Uppsala Sweden phone +46 18 471 4105 fax +46 18 471 4003 mats.karlsson@farmbio.uu.se