Re: IOV effects

From: Mats Karlsson Date: November 23, 1999 technical Source: cognigencorp.com
Date: Tue, 23 Nov 1999 16:55:16 +0100 From: Mats Karlsson <Mats.Karlsson@biof.uu.se> Subject: Re: IOV effects Hi I agree with all what Pascal wrote apart from > when a patient has only one occasion he carries absolutely no information > about IOV. An equally true statement is that he carries no information about IIV. That truth being that he carries info only about the sum of the two and information from other individuals will have to be used to partition the total variability. > With NONMEM, if you try to estimate IOV using a dataset with patients > having only one occasion, you should get an estimate of IOV omega close > to 1E-8 Actually, IIV and IOV are unidentifyable, they can take on a multitude of values, but should be highly correlated. Mats

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Nov 23, 1999 James IOV effects (inter-occasion variability)
Nov 23, 1999 Mats Karlsson Re: IOV effects
Nov 23, 1999 Pascal Girard Re: IOV effects
Nov 23, 1999 James Re: IOV effects
Nov 23, 1999 Vladimir Piotrovskij RE: IOV effects
Nov 23, 1999 James RE: IOV effects
Nov 23, 1999 Mats Karlsson Re: IOV effects
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