RE: NONMEM and identification of drug-drug interactions

From: Mats Karlsson <mats.karlsson@biof.uu.se> Subject: RE: NONMEM and identification of drug-drug interactions Date: 19 Dec 1997 05:21:10 -0500 Katya, I couldn't find your earlier message, so the answer has to be a general one. If you found that drugs in a therapeutic area dont interact with your drug, it seems reasonable to claim that the action of those agents (whether it is diuresis, lowering of gastric pH or something else) does not seem to influence the PK of your drug. To make the claim that there is no PK interaction, is harder, especially if the group of drugs is heterogeneous with respect to binding, metabolism and transport mechanisms. However, I think that a statement that says: no influence on the PK of X was found when concomitant medication was grouped as beta-blockers (n=88), NSAIDS (n=33), etc, would still be useful. It conveys some reassurance and for those knowledgeable in pharmacokinetics, they would be able to do the distinction that the information may be more relevant for relatively homogeneous groups. Merry Christmas, Mats PS For those of you that asked for the presentation in a different format, I will send it when I get back to work (Im working from home now).