RE: Interpreting IOV
From: "Mats Karlsson" mats.karlsson@farmbio.uu.se
Subject: RE: [NMusers] Interpreting IOV
Date: Fri, 16 Sep 2005 08:20:46 +0200
Dear Pete,
It would be easier to say if something about the drug and study population
and study circumstances was known. Changing protein binding or blood
composition (w/ or w/o food), and different levels of physical activity
could be explanations. On the other hand it could always be modeling
nonsense.
Best regards,
Mats
--
Mats Karlsson, PhD
Professor of Pharmacometrics
Div. of Pharmacokinetics and Drug Therapy
Dept. of Pharmaceutical Biosciences
Faculty of Pharmacy
Uppsala University
Box 591
SE-751 24 Uppsala
Sweden
phone +46 18 471 4105
fax +46 18 471 4003
mats.karlsson@farmbio.uu.se