Rate constants

From: Mats Karlsson <Mats.Karlsson@biof.uu.se> Subject: Rate constants Date: Mon, 27 Nov 2000 22:28:05 +0100 Those interested in real problems can stop reading here! Usually we model rate constants (ka, keo, kout, ...) with exponential models (ka=THETA(.)*EXP(ETA(.))). Is there any reason to believe that this should be better than modelling the corresponding half-lives or transit/residence times instead (e.g. MAT=THETA(.)*EXP(ETA(.))? I usually find it easier to keep track of how reasonable parameters are on the time rather than inverse time scale, so the time scale would in that respect to prefer. Best regards, Mats -- Mats Karlsson, PhD Professor of Biopharmaceutics and Pharmacokinetics Div. of Biopharmaceutics and Pharmacokinetics Dept of Pharmacy Faculty of Pharmacy Uppsala University Box 580 SE-751 23 Uppsala Sweden phone +46 18 471 4105 fax +46 18 471 4003 mats.karlsson@biof.uu.se