RE: VPC with Mixture Model

Dear Satyendra, Interesting question. I don't think there is much written about this, but I may be wrong. What I would not do is to try to stratify based on estimated subpopulation allocation ("EST"). Rather I would use the same VPCs as if there had been no mixture model. Possibly what you could do is be more careful in your choice of prediction intervals to display. For example, if you have a subpopulation of poor metabolizers of about 5%, displaying only median and interquartile range PIs may not be a good idea. Best regards, Mats Mats Karlsson, PhD Professor of Pharmacometrics Dept of Pharmaceutical Biosciences Uppsala University Box 591 751 24 Uppsala Sweden phone: +46 18 4714105 fax: +46 18 471 4003