RE: Probabilistic model

From: "Mats Karlsson" Subject: RE: [NMusers] Probabilistic model Date: Thu, May 19, 2005 2:46 am Hi Nick, For a 6-grade scale (0-5), predictions outside the range has even less meaning than those in between the categories. Therefore, we needed to put quite some effort into appropriate constraining such that the model could simulate well. Also, maybe not surprising, it is difficult to create a residual error model that appropriately describes the residual error when the observed data are constrained to 6 levels and a considerable amount lies at the edges of the prediction range. Best regards, Mats -- Mats Karlsson, PhD Professor of Pharmacometrics Div. of Pharmacokinetics and Drug Therapy Dept. of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 SE-751 24 Uppsala Sweden phone +46 18 471 4105 fax +46 18 471 4003 mats.karlsson@farmbio.uu.se