RE: Renal CL estimations

From: "Mats Karlsson" mats.karlsson@farmbio.uu.se Subject: RE:[NMusers] Renal CL estimations Date: Wed, June 16, 2004 1:48 am Hi Batul, If you have measured amount in urine over the period 0-24 h. Making an observation in compartment 2 at 24 h will give you a prediction of just that. You dont need to think in terms of excretion rate, neither in observations nor predictions. The coding becomes a bit tricker if you have multiple urine observations as urine compartment needs to be emptied and collection restarted, which is done in the data file by using EVID 2 and ON/OFF signaled through CMT = 2 or -2. I send some coding separately. Whenever you observae amounts in urine, the time of the observation is when you made it, that is at the end of the observation interval. Parametrisation with CLR and CLNR is likely to involve less covariance between parameters than CL and FE. Best regards, Mats -- Mats Karlsson, PhD Professor of Pharmacometrics Div. of Pharmacokinetics and Drug Therapy Dept. of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 SE-751 24 Uppsala Sweden phone +46 18 471 4105 fax +46 18 471 4003 mats.karlsson@farmbio.uu.se