RE: Outliers and the FDA guideline

From: Mats Karlsson [mailto:mats.karlsson@farmbio.uu.se] Subject: RE: [NMusers] Outliers and the FDA guideline Date: Monday, August 23, 2004 8:22 AM Hi Matt, Nice advice. I was just wondering about a technicality. In applying the mixture model to Tlag in a visit-specific manner, did you treat each visit as a separate subject or did you apply such a mixture while keeping the individual records intact (ie handling occasions as such not as IDs). If the latter, it would be nice to see some code. Thanks, Mats -- Mats Karlsson, PhD Professor of Pharmacometrics Div. of Pharmacokinetics and Drug Therapy Dept. of Pharmaceutical Biosciences Faculty of Pharmacy Uppsala University Box 591 SE-751 24 Uppsala Sweden phone +46 18 471 4105 fax +46 18 471 4003 mats.karlsson@farmbio.uu.se