RE: Simulo: a new service for drug trial simulation
Hi,
In many cases you don't even need to use $ABB COMRES to do response-adaptive
designs, simulated response could just impact a bioavailability term (Fx) of
the next dose(s) to indicate dose change. I'm sure that more complex
response-adaptive designs could benefit from a dedicated software though.
Best regards,
Mats
Mats Karlsson, PhD
Professor of Pharmacometrics
Dept of Pharmaceutical Biosciences
Faculty of Pharmacy
Uppsala University
Box 591
75124 Uppsala
Phone: +46 18 4714105
Fax + 46 18 4714003
www.farmbio.uu.se/research/researchgroups/pharmacometrics/
Quoted reply history
-----Original Message-----
From: [email protected] [mailto:[email protected]] On
Behalf Of Leonid Gibiansky
Sent: Tuesday, June 23, 2015 4:14 PM
To: Faelens, Ruben (Belgium); [email protected]
Subject: Re: [NMusers] Simulo: a new service for drug trial simulation
Actually, nonmem can be used to simulate the response-based dose adaptation
without iteratively rerunning your model, with single simulation (using $ABB
COMRES functionality to pass simulated response to the dose-adjustment
algorithm code), although it is indeed cumbersome
Leonid
--------------------------------------
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566
On 6/23/2015 4:48 AM, Faelens, Ruben (Belgium) wrote:
> Dear NONMEM users,
>
> We all know how difficult it is to simulate full drug trials using
> NONMEM. It is often necessary to generate the full dosing scheme(s)
> beforehand, and response-based dose adaptation requires iteratively
> rerunning your model until you have the results you are happy with.
>
> At SGS Exprimo, we have been working for 4 years to develop a new
> software that makes drug trial simulation much more straight-forward.
> The software has been developed in collaboration with Roche and has
> been used internally within SGS Exprimo for the last 2 years. We are
> now presenting it to the public as a new consultancy service. You may
> have seen us in Crete at PAGE 2015.
>
> We invite you to visit our website www.simulo.eu
> http://www.simulo.eu or contact us directly to request an on-site
> demo or web conference, or to ask any questions you may have.
>
> We look forward to hearing from you.
>
> Kind regards,
>
> Ruben Faelens for SGS Exprimo
>
> *Ruben Faelens, MSc*
> *Life Science Services - Exprimo*
> IT Scientist
>
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