Mark Sale

238 messages, 1994–2025

Date Subject
Feb 22, 1994 Unknown Dosing Histories technical
Jan 16, 1995 WWW Server Site for NONMEM Discussions technical
Apr 19, 1995 -big option on PC technical
Jan 22, 1996 Windows NT technical
Nov 27, 1996 Discrete parameters technical
Jul 23, 1997 OMEGA and SIGMA in INFN technical
Sep 26, 1997 Re: arterio-venous modeling technical
Oct 10, 1997 RE: Software for PCs technical
Oct 10, 1997 RE: Software for PCs technical
Dec 04, 1998 NONMEM as a dll technical
Nov 12, 1999 RE: Standard error of 'secondary' parameters technical
Nov 15, 1999 RE: Standard error of 'secondary' parameters technical
Apr 21, 2000 Model building algorithm technical
Apr 21, 2000 RE: Model building algorithm technical
Apr 25, 2000 RE: Model building algorithm technical
Apr 25, 2000 RE: Model building algorithm technical
May 31, 2000 RE: Software and procedures for conducting and reporting on NONME M analyses in clinical reports technical
Jun 05, 2000 RE: weighting observed data technical
Sep 15, 2000 RE: Out of environment space technical
Apr 26, 2001 RE:constant CV technical
Apr 26, 2001 RE: question with running nonmem technical
May 02, 2001 RE: The number of columns (variables) in $INPUT block technical
May 04, 2001 NONMEM compliance technical
May 07, 2001 RE: NONMEM priority on windows NT/2000 technical
May 08, 2001 RE: NONMEM priority on windows NT/2000 technical
May 31, 2001 RE: Covariate screening technical
Jul 13, 2001 RE: Akaike information criterion technical
Oct 05, 2001 NONMEM conc-reponse analysis for depression technical
Oct 11, 2001 RE: Distributive Computing technical
Oct 15, 2001 RE: Distributive Computing technical
Aug 06, 2002 Comparison of simulated trials to real trials technical
Aug 07, 2002 RE: Comparison of simulated trials to real trials technical
Sep 26, 2003 RE: order of covariate inclusion -> avoiding stepwise approaches technical
Sep 26, 2003 RE: order of covariate inclusion -> avoiding stepwise approaches -> abandoning exploratory analysis? technical
Sep 26, 2003 RE: order of covariate inclusion -> avoiding stepwise approaches -> abandoning exploratory analysis? technical
Sep 29, 2003 RE: order of covariate inclusion -> avoiding stepwise approaches -> abandoning exploratory analysis? technical
Sep 29, 2003 RE: order of covariate inclusion -> avoiding stepwise a pproaches -> abandoning exploratory analysis? technical
Oct 22, 2003 Re: Filing technical
Oct 22, 2003 Re: Filing technical
Oct 22, 2003 RE: grid computing technical
May 30, 2004 RE: PK models for rich and sparse sampling technical
May 31, 2004 RE: PK models for rich and sparse sampling technical
Jun 01, 2004 RE: $OMEGA blocks and log-likelihood profiling technical
Jun 01, 2004 RE: PK models for rich and sparse sampling technical
Jun 01, 2004 RE: PK models for rich and sparse sampling technical
Jun 02, 2004 RE: PK models for rich and sparse sampling technical
Nov 18, 2004 RE: PD lag time in $DES technical
Dec 07, 2004 Re: SAS program or SAS macro to prepare NonMem readydata technical
Jan 26, 2005 questions on ODE solver errors technical
Mar 01, 2005 Re: Model building question technical
Mar 01, 2005 Re: Model building question technical
Mar 02, 2005 Re: Model building question technical
Apr 18, 2005 RE: simulation of dose escalation study technical
Aug 11, 2005 Re: Any way to change the maximum input data item no.? technical
Aug 11, 2005 Re: Any way to change the maximum input data item no.? technical
Aug 15, 2005 Re: faster PC to run nmv technical
Aug 24, 2005 Re: exceeding max. number of INPUT-variables technical
Aug 24, 2005 Re: exceeding max. number of INPUT-variables technical
Aug 26, 2005 Re: Installation error message. technical
Sep 15, 2005 RE: Re[2]: Covariance: Matrix=S or Matrix=R technical
Sep 16, 2005 Re: Interpreting IOV technical
Nov 02, 2005 RE: DOS emulation window issue technical
Nov 03, 2005 RE: DOS emulation window issue technical
Nov 04, 2005 RE: DOS emulation window issue technical
Nov 22, 2005 Re: processor choice technical
Dec 13, 2005 Re: Looking for faster CPU technical
Dec 23, 2005 Re: question of $INPUT: NO. OF DATA ITEMS EXCEEDS 20 technical
Jan 17, 2006 RE: covariate selection question technical
Jan 17, 2006 RE: covariate selection question technical
Jan 18, 2006 RE: covariate selection question technical
Jan 18, 2006 RE: covariate selection question technical
Jan 20, 2006 RE: covariate selection question technical
Jan 20, 2006 RE: covariate selection question technical
Jan 26, 2006 Re: NONMEM technical
Feb 01, 2006 Re: 100% CPU with NONMEM technical
Mar 29, 2006 RE: GAM analysis and further action technical
Mar 30, 2006 RE: What are the best studies to combine? technical
Mar 31, 2006 RE: RE: What are the best studies to combine? technical
Mar 31, 2006 RE: RE: RE: What are the best studies to combine? technical
Apr 07, 2006 NONMEM graphics technical
Apr 26, 2006 Re: Placebo in indirect PD models technical
May 01, 2006 RE: Placebo in indirect PD models technical
Jun 11, 2006 RE: Simulation of Steady state concentration of Phenytoin technical
Jul 07, 2006 RE: Covariate models of genetic polymorphisms technical
Jul 11, 2006 RE: SS indication for dataset with BID dose and AM dose different from PM dose. technical
Jul 17, 2006 EMEA pop pk reporting technical
Jul 18, 2006 RE: Reporting of interim models in Pop PK Reports technical
Jul 18, 2006 RE: Reporting of interim models in Pop PK Reports technical
Aug 01, 2006 Re: Problems with an apparent compiler-senstive model technical
Aug 02, 2006 Re: Problems with an apparent compiler-senstive model technical
Aug 02, 2006 Re: Problems with an apparent compiler-senstive model technical
Aug 03, 2006 Re: Problems with an apparent compiler-senstive model technical
Aug 11, 2006 RE: Hi,dear all ,some new questions occur ! technical
Aug 16, 2006 RE: different results from two computers technical
Aug 18, 2006 Automated NONMEM model selection patent issued technical
Aug 21, 2006 RE: Transference of data into NONMEM technical
Aug 21, 2006 RE: Transference of data into NONMEM technical
Aug 21, 2006 RE: Transference of data into NONMEM technical
Aug 27, 2006 RE: Can we increase maximum number of function evaluations? technical
Aug 28, 2006 RE: Can we increase maximum number of function evaluations? technical
Sep 14, 2006 Re: NONMEM technical
Sep 14, 2006 Re: NONMEM technical
Sep 14, 2006 Re: NONMEM technical
Sep 14, 2006 Re: NONMEM technical
Sep 15, 2006 Re: NONMEM technical
Sep 25, 2006 RE: WRES AND OUTLIER IDENTIFICATION/EXCLUSION technical
Sep 26, 2006 Re: Bootstrap question technical
Nov 30, 2006 RE: Welcome to the new small sample size world of NONMEM VI technical
Nov 30, 2006 RE: MAXIDS=10000 technical
Dec 01, 2006 RE: Welcome to the new small sample size world of NONMEM VI technical
Dec 01, 2006 RE: MAXIDS=10000 technical
Dec 01, 2006 RE: MAXIDS=10000 technical
Feb 07, 2007 Sample size/power in NONMEM technical
Feb 15, 2007 RE: Simulation with covariates technical
Feb 26, 2007 RE: WARNING 48 technical
Feb 28, 2007 RE: create simulation file for 5000 patients ? technical
Mar 12, 2007 RE: Linear speedup of NONMEM on quad-core CPUs? technical
Mar 19, 2007 General question on modeling technical
Mar 20, 2007 RE: General question on modeling technical
Mar 21, 2007 RE: General question on modeling technical
Mar 29, 2007 RE: input conversion error technical
May 22, 2007 RE: No Fit file technical
May 23, 2007 RE: No Fit file -> bug or not a bug? technical
May 27, 2007 RE: NONMEM ODE solver technical
May 28, 2007 RE: NONMEM ODE solver technical
May 29, 2007 RE: NONMEM ODE solver technical
May 30, 2007 RE: How to generate an output file with individual parameters at each iteration technical
Jul 07, 2007 NONMEM output viewer technical
Jul 13, 2007 PD for monoclonal antibodies technical
Jul 17, 2007 RE: Simultaneous PK and Cell Life Span PD modeling technical
Jul 18, 2007 RE: How to solve it? ERROR: PARAMETER ESTIMATE IS NEAR ITS BOUNDARY technical
Jul 19, 2007 RE: Simultaneous PK and Cell Life Span PD modeling technical
Jul 20, 2007 updated NONMEM output viewer technical
Jul 21, 2007 RE: Minimization terminated ? technical
Jul 31, 2007 RE: PK analysis of data from different occasions technical
Aug 14, 2007 RE: Model Comparison and Viewing of Output technical
Sep 13, 2007 Data checking macro technical
Oct 12, 2007 RE: permissible band matrix technical
Oct 25, 2007 RE: Reporting Modeling Results technical
Oct 26, 2007 RE: Reporting Modeling Results technical
Oct 27, 2007 RE: Reporting Modeling Results technical
Nov 05, 2007 Declining to do simulation bug/feature technical
Dec 07, 2007 RE: error (157) forrtl: severe technical
Jan 29, 2008 Why does covariance fail? technical
Feb 01, 2008 RE: RE : output SE of population PK parameters in Nonmem technical
Feb 06, 2008 RE: output SE of population PK parameters in Nonmem technical
Feb 07, 2008 RE: output SE of population PK parameters in Nonmem technical
Mar 31, 2008 RE: automating the writing of models technical
Apr 01, 2008 RE: automating the writing of models technical
May 21, 2008 Presentation on modeling by Next Level Solutions technical
Jul 17, 2008 RE: Build a cell-cycle based tumor growth model technical
Jul 19, 2008 algorithm limits technical
Jul 20, 2008 RE: algorithm limits technical
Jul 21, 2008 RE: algorithm limits technical
Jul 22, 2008 RE: How to code vomit event as absorption lag and lost of amount in administration comp. technical
Jul 22, 2008 RE: How to code vomit event as absorption lag and lost of amountin administration comp. technical
Jul 22, 2008 RE: How to code vomit event as absorption lag and lost of amount in administration comp. technical
Jul 22, 2008 RE: How to code vomit event as absorption lag and lost of amountin administration comp. technical
Aug 21, 2008 RE: Any solutions to both "minimization terminated" and "high" relative bioavailability technical
Aug 21, 2008 RE: Any solutions to both "minimization terminated" and "high" relative bioavailability technical
Sep 02, 2008 unbalanced design technical
Sep 12, 2008 RE: What would the impact be, if NONMEM runs 10 times faster than now? technical
Sep 12, 2008 RE: What would the impact be, if NONMEM runs 10 times faster than now? technical
Nov 13, 2008 Extremely geeky question technical
Nov 19, 2008 RE: Models that abort before convergence technical
Nov 21, 2008 RE: Models that abort before convergence Addendum technical
Mar 16, 2009 RE: 20 variable limit in $INPUT technical
Apr 14, 2009 RE: OMEGA BLOCK with mixture model? technical
Apr 15, 2009 RE: OMEGA selection technical
Apr 21, 2009 RE: NONMEM with ACCELLERANT technical
Apr 23, 2009 RE: OMEGA selection technical
Jun 04, 2009 RE: Coding a triple absorption model technical
Aug 06, 2009 RE: Steady state model technical
Aug 24, 2009 RE: Honest measurements technical
Aug 25, 2009 RE: What does convergence/covariance show? technical
Oct 26, 2009 RE: $COV UNCONDITIONAL PRINT=E technical
Dec 01, 2009 request for assistance technical
Aug 26, 2010 RE: Block versus diagonal omega technical
Aug 27, 2010 RE: Block versus diagonal omega technical
Aug 29, 2010 RE: Trial optimization across multiple endpoints technical
Aug 30, 2010 RE: FW: Block versus diagonal omega technical
Sep 01, 2010 RE: $PK ADVAN6 technical
Jan 06, 2011 RE: outsourcing PK/PD analysis - help wanted job
Jan 26, 2011 RE: High spec PC setup for NONMEM - recommendations? technical
Feb 03, 2011 Inclusion of Analytical Expressions in NONMEM control file technical
Mar 10, 2011 RE: NONMEM 7.1.2 run time in Windows 7 technical
Mar 16, 2011 RE: GPU port for NONMEM technical
May 20, 2011 RE: Simple parallel benchmark for Nonmem 7.2 with large Bayes problem technical
May 24, 2011 Parallel benchmarks technical
Jun 02, 2011 RE: Modeling concentration data with imprecise sampling time technical
Oct 30, 2011 Declining to simulate technical
Nov 14, 2011 RE: CycleCloud BigScience Challenge giving away ~8-hours on 30000 core cluster for research technical
Nov 14, 2011 RE: CycleCloud BigScience Challenge giving away ~8-hours on 30000 core cluster for research technical
Feb 13, 2012 RE: NONLINEAR PK MODEL ERROR technical
Mar 06, 2012 RE: Dual inhibitor synergy model technical
Mar 15, 2012 RE: NONMEM compiler technical
May 24, 2012 RE: RE: Successful minimization and covariance technical
Jun 18, 2012 RE: How to model delayed count data due to time needed to form an event technical
Jun 20, 2012 RE: Simulation: MAX no of observations per individual exceed technical
Aug 12, 2012 RE: Intel vs AMD technical
Aug 13, 2012 RE: Intel vs AMD technical
Oct 23, 2013 RE: Change of NSIG or R matrix technical
Oct 25, 2013 RE: Change of NSIG or R matrix technical
Feb 24, 2015 Error in parallel nonmem - related to file size? technical
Feb 25, 2015 Error in parallel nonmem - related to file size? technical
May 29, 2015 Modeling accelerated phase of malignancy technical
May 30, 2015 RE: Modeling accelerated phase of malignancy technical
Jul 27, 2015 RE: Is it reasonable to add covarite to PD parameters kin or kout? technical
Sep 27, 2015 Error in table step technical
Sep 28, 2015 Re: Error in table step technical
Nov 16, 2015 Pediatric brain scaling technical
Dec 08, 2015 Re: setup of parallel processing and supporting software - help wanted job
Dec 08, 2015 Re: setup of parallel processing and supporting software - help wanted job
Dec 09, 2015 Re: setup of parallel processing and supporting software - help wanted job
Dec 09, 2015 Re: setup of parallel processing and supporting software - help wanted job
Feb 19, 2016 Mixture model with logistic regression technical
Feb 20, 2016 Re: Mixture model with logistic regression technical
Feb 21, 2016 Re: Mixture model with logistic regression technical
Jul 17, 2016 Laplacian, BQL and initial estimates technical
Jul 18, 2016 Re: Laplacian, BQL and initial estimates technical
Nov 11, 2016 $PRIOR with normal for OMEGA? technical
Aug 23, 2018 IMPMAP behavior question technical
Jan 07, 2019 run NMFE without actually executing technical
Feb 04, 2019 Different OBJ after covariance with parallel and IMPMAP technical
Apr 16, 2019 Microsoft MPI technical
Nov 06, 2019 Re: Using evid 0 before dosing technical
Nov 29, 2019 LIBDECIMAL.LIB MISSING? technical
Feb 14, 2020 error message from xpose technical
Aug 15, 2022 Open source package for AI/Machine learning model selection in NONMEM technical
Dec 17, 2022 Simulate with parameter uncertainty technical
Jan 26, 2024 RE: NONMEM Error on SAEM but not FOCEI technical
Mar 06, 2024 Announcement of Pre Conference workshop in RsNLME and machine learning with pyDarwin event
Apr 22, 2024 PyDarwin and RsNLME course at PAGE event
Jun 04, 2024 FREE - RsNLME and R tools at PAGE on June 25th event
Aug 03, 2024 RE: Sad news about Dr. Ludden news
Apr 04, 2025 Machine learning course at PAGE event
Apr 22, 2025 Page course on Machine learning model selection in NONMEM and NLME still available event
Oct 09, 2025 Error from NUTS estimation technical