Unknown Dosing Histories

I have often thought that an elegant study would be to use the Medication Events Monitoing System (MEMS, Aprex Corporation) to get real dosing histories for an outpatient study. I did a pilot study of this sort while a fellow and am planning a larger study of adolescent compliance/pk/response to HIV therapy. The MEMS should give reasonable data on when the doses are taken, and if the study is still in the design phase could be used.